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Nature 440, 999-1000 (20 April 2006) | doi:10.1038/440999a; Published online 19 April 2006
Neuroscience: Spikes too kinky in the cortex?
Boris Gutkin1 & G. Bard Ermentrout2
Abstract
The Hodgkin–Huxley theory that explains the mechanism of how neurons fire forms the cornerstone of computational neuroscience. But something it hasn't predicted is happening in the brain cortex.
Neurons encode and transmit information by generating action potentials, or 'spikes' of voltage that sweep along their membranes (Box 1). It has been 50 years since Hodgkin and Huxley1 proposed a mechanistic model by which such spikes are generated in an electrically excitable membrane.
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