Supplementary information

From the following article:

Robust Salmonella metabolism limits possibilities for new antimicrobials

Daniel Becker, Matthias Selbach, Claudia Rollenhagen, Matthias Ballmaier, Thomas F. Meyer, Matthias Mann and Dirk Bumann

Nature 440, 303-307 (16 March 2006)

doi:10.1038/nature04616

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Supplementary Figure 1

Overview of Salmonella metabolism in a mouse enteritis model.

Supplementary Table 1

Published Salmonella mutant phenotypes in typhoid fever models.

Supplementary Table 2

Salmonella genes that are non-functional in serovars causing systemic disease.

Supplementary Table 3

Summary of functional and proteome evidence for Salmonella metabolic enzymes and pathways in typhoid fever and enteritis models.

Supplementary Table 4

Salmonella genes with controversial in vitro phenotypes.

Supplementary Table 5

Salmonella proteome data for typhoid fever and enteritis models.

Supplementary Table 6

Growth rates of Salmonella mutants in typhoid fever and enteritis models.

Supplementary Table 7

Metabolites likely to be present in Salmonella during typhoid fever and/or enteritis.

Supplementary Table 8

Properties of Salmonella enzymes representing potential antimicrobial targets.

Supplementary Table 9

Salmonella nutrition during typhoid fever and enteritis.

Supplementary Methods

Technical details of experimental methods used in this study.

Supplementary Notes

This file contains additional references.

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