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Nature 440, 40 (2 March 2006) | doi:10.1038/440040a; Published online 1 March 2006
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Direct Molecular Detection of Proteins and Nucleic Acids
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Assistant or Associate Professor, Section of Anatomic Pathology
- The Medical College of Georgia
- Augusta, Georgia, USA
Chemical Reaction Engineering & Reactor Design
- Praj Matrix - Praj Industries Ltd
- Pune, Maharashtra Pune-411021 India
Structural biology: Designer labels
Stanley J. Opella1
Abstract
An innovative approach to the isotopic labelling of proteins places the determination of the structures of larger proteins — particularly those in solution — within reach, while improving the accuracy of the method.
With completion of the sequencing of the human and many other genomes, molecular biology is able to return to its roots to focus on, as Francis Crick1 put it, "the description of [proteins, viruses, bacteria and chromosomes] in terms of their structure, i.e.
- Stanley J. Opella is in the Department of Chemistry and Biochemistry, University of California, San Diego, 9500 Gilman Drive, La Jolla, California 92093-0307, USA. Email: sopella@ucsd.edu
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