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Nature 440, 38-39 (2 March 2006) | doi:10.1038/440038b; Published online 1 March 2006
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Assistant Professor
- University of Michigan
- Michigan, MI 48109 United States
Faculty Positions
- University of Texas Medical Branch
- Galveston, TX United States
Cell biology: A break in the chain?
Keith Burridge1
Abstract
How chains of proteins link transmembrane cell–cell adhesion molecules to the cell's inner scaffold was standard textbook material. But recent research challenges the accepted model, opening a new chapter in the field.
Many of the adhesion molecules that enable cells to stick together are anchored to part of the cell's internal scaffold — the actin cytoskeleton. This association is usually indirect and serves to transmit tension to sites of adhesion, to cluster adhesion molecules and to provide a framework for the assembly of complexes of signalling proteins.
- Keith Burridge is in the Department of Cell and Developmental Biology, and the Lineberger Comprehensive Cancer Center, University of North Carolina, Chapel Hill, North Carolina 27599, USA.
Email: Keith_Burridge@med.unc.edu
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