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Nature 439, 546-548 (2 February 2006) | doi:10.1038/439546a; Published online 1 February 2006

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Neurobiology: Memories of a fruitfly

William G. Quinn1

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Despite its tiny size, the fruitfly brain is staggeringly intricate. So teasing apart how it remembers things — even a simple line pattern — is a daunting task. Progress is being made, thanks to genetic innovations.

Neuroscientists these days have a satisfactory understanding of how individual neurons work and of how they communicate with their immediate neighbours. By contrast, understanding at the next level of organization is hazier; for example, how neurons form functional circuits, how these circuits encode behaviour and particularly how experience changes the activity and connectivity in circuits to alter behaviour.

  1. William G. Quinn is in the Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, 77 Massachusetts Avenue, Cambridge, Massachusetts 02139, USA.
    Email: cquinn@mit.edu

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