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Nature 439, 539 (2 February 2006) | doi:10.1038/439539a; Published online 1 February 2006

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Concept The third Bond

Simon Wain-Hobson1

  1. Simon Wain-Hobson is at the Pasteur Institute, Paris.

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When James Watson and Francis Crick unveiled their structure of DNA, one of the two kinds of base pair in the molecule was given two hydrogen bonds instead of three. Who spotted the third bond and when?

It is a truth universally acknowledged that a guanine–cytosine (GC) base pair has three hydrogen bonds whereas adenine–thymine (AT) has two. But James Watson and Francis Crick didn't see it that way back in 1953 when they published the structure of DNA.

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