Editorials

Chinese hesitancy on avian flu p369

The time has come for China to start pulling its weight as a participant in the global response to bird flu — and to learn to collaborate more openly.

doi:10.1038/439369a

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A firm foundation? p369

After more than thirty years, a European science agency is struggling to establish a clear identity.

doi:10.1038/439369b

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Warming to economics p370

Climate research can only gain from closer collaboration with economists.

doi:10.1038/439370a

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Research Highlights

Research highlights p372

doi:10.1038/439372a

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News

The costs of global warming p374

Efforts to forecast how Earth's future climate will affect us must consider the economic growth of both rich and poor nations. But there are doubts over the theories being used, as Quirin Schiermeier explains.

Quirin Schiermeier

doi:10.1038/439374a

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Panel quits in row over sonar damage p376

Programme to test how noise affects marine mammals seems doomed.

Rex Dalton

doi:10.1038/439376a

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Nations wrestle to host future telescope p377

Chile and Mexico square up in battle for next-generation sky survey.

Tony Reichhardt

doi:10.1038/439377a

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Treasure island: pinning down a model ecosystem p378

Every species on paradise isle to be catalogued.

Erika Check

doi:10.1038/439378a

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A brief history of Pluto p378

As NASA's New Horizons spacecraft sets off on its long trip to Pluto, Mark Peplow looks at how our view of the Solar System's outskirts has changed.

doi:10.1038/439378b

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Bad data fail to halt patents p379

Concerns raised over impact of errors in applications.

Eugenie Samuel Reich

doi:10.1038/439379a

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Sidelines p380

doi:10.1038/439380a

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India's ban on foreign boats hinders tsunami research p380

Frustrated geologists want access to Indian waters.

Jim Giles

doi:10.1038/439380b

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News in brief p381

doi:10.1038/439381a

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Correction p381

doi:10.1038/439381b

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News Features

China: Open season p382

SARS caught China unawares. But the ensuing struggle to characterize and contain the virus has put the country's work on infectious diseases back on target. Apoorva Mandavilli reports.

doi:10.1038/439382a

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Genomics: Discovery in the dirt p384

Soil microbes are notoriously hard to culture, so how can we make the ground yield its secrets? Virginia Gewin finds that genetic sequencing — of samples not species — may be the answer.

doi:10.1038/439384a

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Literary darwinism: Textual selection p388

Can reading the classics through Charles Darwin's spectacles reawaken literary study? John Whitfield reports.

doi:10.1038/439388a

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Business

The right combination p390

Instead of the painstaking process of developing new drugs, one Boston-based company is making its mark by pairing up those we already have. Meredith Wadman reports.

doi:10.1038/439390a

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In brief p391

doi:10.1038/439391a

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Market watch p391

Colin Macilwain

doi:10.1038/439391b

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Correspondence

Biodiversity data are out of local taxonomists' reach p392

Donat Agosti

doi:10.1038/439392a

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No clear evidence to disprove optics thesis p392

Charles M. Falco

doi:10.1038/439392b

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Branding can be justified in vital conservation research p392

C. R. McMahon, C. J. A. Bradshaw and G. C. Hays

doi:10.1038/439392c

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Don't forget randomness is still just a hypothesis p392

Juergen Schmidhuber

doi:10.1038/439392d

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Books and Arts

Agents of destruction p393

An in-depth look at the state of biological-weapons programmes across the world.

Jens H. Kuhn reviews Deadly Cultures: Biological Weapons Since 1945 edited by Mark Wheelis, Lajos Rózsa & Malcolm Dando

doi:10.1038/439393a

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What is it like to speed date? p394

Adina Roskies reviews Conversations on Consciousness by Susan Blackmore

doi:10.1038/439394a

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Burning ambition p395

Bernadette Bensaude-Vincent reviews A World on Fire: A Heretic, an Aristocrat, and the Race to Discover Oxygen by Joe Jackson

doi:10.1038/439395a

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Science in culture: Stamping his authority p396

The Hwang scandal highlights the dangers of hyping science.

Martin Kemp

doi:10.1038/439396a

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Essay

A better than perfect match p397

Entanglement, a mind-boggling form of correlations that exist between objects in the quantum world, is helping to explain phenomena and jazzing up computing. But it looks as if much more may be in store.

Vlatko Vedral

doi:10.1038/439397a

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News and Views

Physiology: Plants on a different scale p399

Is there a unified theory that relates size and metabolic rate across all organisms? Maybe not, according to the results of experiments that measured respiration in plants of widely varying mass.

Lars O. Hedin

doi:10.1038/439399a

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Extrasolar planets: Light through a gravitational lens p400

A planet with a mass lower than that of Neptune has been detected as its gravity bent the light from a remote star. This lensing technique adds to our arsenal for spotting small planets outside the Solar System.

Didier Queloz

doi:10.1038/439400a

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Metabolism: Bile acids heat things up p402

Thyroid hormone causes fat loss, but harnessing this action to treat obesity is difficult because it is associated with harmful side effects. However, bile acids generate active thyroid hormone just where it is needed.

John D. Baxter and Paul Webb

doi:10.1038/439402a

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Travel: Fitting the bill p402

Rory Howlett

doi:10.1038/439402b

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50 & 100 years ago p403

doi:10.1038/439403a

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Development: Twists of fate in the brain p404

How does the complex array of cell types and functions in the mammalian brain develop? Tracking cells by gene expression shows how their fates derive from organization within the simple embryonic neural tube.

Richard V. Pearse, II and Clifford J Tabin

doi:10.1038/439404a

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Materials science: A new order for metallic glasses p405

Like normal glass, metallic glasses lack long-range order. But experiments and simulations show that, on the nanoscale, clusters of atoms interconnect in these materials to form highly structured 'superclusters'.

Alain Reza Yavari

doi:10.1038/439405a

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DNA repair: Tails of histones lost p406

A double-stranded break in DNA can profoundly destabilize a cell's genome. But how does the cell recognize the damage and halt division until it can be fixed? The answer lies in the proteins that package and unravel DNA.

André Nussenzweig and Tanya Paull

doi:10.1038/439406a

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Brief Communications

Biogeography: Molecular trails from hitch-hiking snails p409

Migrating birds may have transported the Balea land snail across vast distances to remote islands.

Edmund Gittenberger, Dick S. J. Groenenberg, Bas Kokshoorn and Richard C. Preece

doi:10.1038/439409a

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Brief Communications Arising

Earth science: A wet mantle conductor? pE3

Marc Hirschmann

doi:10.1038/nature04528

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Earth science: A wet mantle conductor? (Reply) pE3

Xiaoge Huang, Yousheng Xu and Shun-ichiro Karato

doi:10.1038/nature04529

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Review

The search for a topographic signature of life p411

William E. Dietrich and J. Taylor Perron

doi:10.1038/nature04452

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Articles

Atomic packing and short-to-medium-range order in metallic glasses p419

H. W. Sheng, W. K. Luo, F. M. Alamgir, J. M. Bai and E. Ma

doi:10.1038/nature04421

Abstract | Full Text | PDF (773K) | Supplementary information

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Policing stabilizes construction of social niches in primates p426

Jessica C. Flack, Michelle Girvan, Frans B. M. de Waal and David C. Krakauer

doi:10.1038/nature04326

Abstract | Full Text | PDF (222K) | Supplementary information

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Epigenetic silencers and Notch collaborate to promote malignant tumours by Rb silencing p430

Dolors Ferres-Marco, Irene Gutierrez-Garcia, Diana M. Vallejo, Jorge Bolivar, Francisco J. Gutierrez-Aviño and Maria Dominguez

doi:10.1038/nature04376

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Letters

Discovery of a cool planet of 5.5 Earth masses through gravitational microlensing p437

J.-P. Beaulieu, D. P. Bennett, P. Fouqué, A. Williams, M. Dominik, U. G. Jørgensen, D. Kubas, A. Cassan, C. Coutures, J. Greenhill, K. Hill, J. Menzies, P. D. Sackett, M. Albrow, S. Brillant, J. A. R. Caldwell, J. J. Calitz, K. H. Cook, E. Corrales, M. Desort, S. Dieters, D. Dominis, J. Donatowicz, M. Hoffman, S. Kane, J.-B. Marquette, R. Martin, P. Meintjes, K. Pollard, K. Sahu, C. Vinter, J. Wambsganss, K. Woller, K. Horne, I. Steele, D. M. Bramich, M. Burgdorf, C. Snodgrass, M. Bode, A. Udalski, M. K. Szymaski, M. Kubiak, T. Wickowski, G. Pietrzyski, I. Soszyski, O. Szewczyk, . Wyrzykowski, B. Paczyski, F. Abe, I. A. Bond, T. R. Britton, A. C. Gilmore, J. B. Hearnshaw, Y. Itow, K. Kamiya, P. M. Kilmartin, A. V. Korpela, K. Masuda, Y. Matsubara, M. Motomura, Y. Muraki, S. Nakamura, C. Okada, K. Ohnishi, N. J. Rattenbury, T. Sako, S. Sato, M. Sasaki, T. Sekiguchi, D. J. Sullivan, P. J. Tristram, P. C. M. Yock and T. Yoshioka

doi:10.1038/nature04441

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Laser acceleration of quasi-monoenergetic MeV ion beams p441

B. M. Hegelich, B. J. Albright, J. Cobble, K. Flippo, S. Letzring, M. Paffett, H. Ruhl, J. Schreiber, R. K. Schulze and J. C. Fernández

doi:10.1038/nature04400

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Laser–plasma acceleration of quasi-monoenergetic protons from microstructured targets p445

H. Schwoerer, S. Pfotenhauer, O. Jäckel, K.-U. Amthor, B. Liesfeld, W. Ziegler, R. Sauerbrey, K. W. D. Ledingham and T. Esirkepov

doi:10.1038/nature04492

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Amplification of chirality in two-dimensional enantiomorphous lattices p449

Roman Fasel, Manfred Parschau and Karl-Heinz Ernst

doi:10.1038/nature04419

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A climatologically significant aerosol longwave indirect effect in the Arctic p453

Dan Lubin and Andrew M. Vogelmann

doi:10.1038/nature04449

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Universal scaling of respiratory metabolism, size and nitrogen in plants p457

Peter B. Reich, Mark G. Tjoelker, Jose-Luis Machado and Jacek Oleksyn

doi:10.1038/nature04282

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The scaling laws of human travel p462

D. Brockmann, L. Hufnagel and T. Geisel

doi:10.1038/nature04292

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Empathic neural responses are modulated by the perceived fairness of others p466

Tania Singer, Ben Seymour, John P. O'Doherty, Klaas E. Stephan, Raymond J. Dolan and Chris D. Frith

doi:10.1038/nature04271

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The adult Drosophila posterior midgut is maintained by pluripotent stem cells p470

Benjamin Ohlstein and Allan Spradling

doi:10.1038/nature04333

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Evidence that stem cells reside in the adult Drosophila midgut epithelium p475

Craig A. Micchelli and Norbert Perrimon

doi:10.1038/nature04371

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Pregnenolone stabilizes microtubules and promotes zebrafish embryonic cell movement p480

Hwei-Jan Hsu, Ming-Ren Liang, Chao-Tsen Chen and Bon-chu Chung

doi:10.1038/nature04436

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Bile acids induce energy expenditure by promoting intracellular thyroid hormone activation p484

Mitsuhiro Watanabe, Sander M. Houten, Chikage Mataki, Marcelo A. Christoffolete, Brian W. Kim, Hiroyuki Sato, Nadia Messaddeq, John W. Harney, Osamu Ezaki, Tatsuhiko Kodama, Kristina Schoonjans, Antonio C. Bianco and Johan Auwerx

doi:10.1038/nature04330

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Architecture of ribonucleoprotein complexes in influenza A virus particles p490

Takeshi Noda, Hiroshi Sagara, Albert Yen, Ayato Takada, Hiroshi Kida, R. Holland Cheng and Yoshihiro Kawaoka

doi:10.1038/nature04378

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Chromatin organization and cell fate switch respond to positional information in Arabidopsis p493

Silvia Costa and Peter Shaw

doi:10.1038/nature04269

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A phosphatase complex that dephosphorylates H2AX regulates DNA damage checkpoint recovery p497

Michael-Christopher Keogh, Jung-Ae Kim, Michael Downey, Jeffrey Fillingham, Dipanjan Chowdhury, Jacob C. Harrison, Megumi Onishi, Nira Datta, Sarah Galicia, Andrew Emili, Judy Lieberman, Xuetong Shen, Stephen Buratowski, James E. Haber, Daniel Durocher, Jack F. Greenblatt and Nevan J. Krogan

doi:10.1038/nature04384

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Corrigendum: Exogenous and endogenous glycolipid antigens activate NKT cells during microbial infections p502

Jochen Mattner, Kristin L. DeBord, Nahed Ismail, Randal D. Goff, Carlos Cantu, III, Dapeng Zhou, Pierre Saint-Mezard, Vivien Wang, Ying Gao, Ning Yin, Kasper Hoebe, Olaf Schneewind, David Walker, Bruce Beutler, Luc Teyton, Paul B. Savage and Albert Bendelac

doi:10.1038/nature04475

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Erratum: Regulated cell-to-cell variation in a cell-fate decision system p502

Alejandro Colman-Lerner, Andrew Gordon, Eduard Serra, Tina Chin, Orna Resnekov, Drew Endy, C. Gustavo Pesce and Roger Brent

doi:10.1038/nature04476

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Corrigendum: Genome sequencing in microfabricated high-density picolitre reactors p502

Marcel Margulies, Michael Egholm, William E. Altman, Said Attiya, Joel S. Bader, Lisa A. Bemben, Jan Berka, Michael S. Braverman, Yi-Ju Chen, Zhoutao Chen, Scott B. Dewell, Alex de Winter, James Drake, Lei Du, Joseph M. Fierro, Robin Forte, Xavier V. Gomes, Brian C. Goodwin, Wen He, Scott Helgesen, Chun He Ho, Steve Hutchinson, Gerard P. Irzyk, Szilveszter C. Jando, Maria L. I. Alenquer, Thomas P. Jarvie, Kshama B. Jirage, Jong-Bum Kim, James R. Knight, Janna R. Lanza, John H. Leamon, William L. Lee, Steven M. Lefkowitz, Ming Lei, Jing Li, Kenton L. Lohman, Hong Lu, Vinod B. Makhijani, Keith E. McDade, Michael P. McKenna, Eugene W. Myers, Elizabeth Nickerson, John R. Nobile, Ramona Plant, Bernard P. Puc, Michael Reifler, Michael T. Ronan, George T. Roth, Gary J. Sarkis, Jan Fredrik Simons, John W. Simpson, Maithreyan Srinivasan, Karrie R. Tartaro, Alexander Tomasz, Kari A. Vogt, Greg A. Volkmer, Shally H. Wang, Yong Wang, Michael P. Weiner, David A. Willoughby, Pengguang Yu, Richard F. Begley and Jonathan M. Rothberg

doi:10.1038/nature04484

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Corrigendum: Genomic sequence of the pathogenic and allergenic filamentous fungus Aspergillus fumigatus p502

William C. Nierman, Arnab Pain, Michael J. Anderson, Jennifer R. Wortman, H. Stanley Kim, Javier Arroyo, Matthew Berriman, Keietsu Abe, David B. Archer, Clara Bermejo, Joan Bennett, Paul Bowyer, Dan Chen, Matthew Collins, Richard Coulsen, Robert Davies, Paul S. Dyer, Mark Farman, Nadia Fedorova, Natalie Fedorova, Tamara V. Feldblyum, Reinhard Fischer, Nigel Fosker, Audrey Fraser, Jose L. García, Maria J. García, Arlette Goble, Gustavo H. Goldman, Katsuya Gomi, Sam Griffith-Jones, Ryan Gwilliam, Brian Haas, Hubertus Haas, David Harris, H. Horiuchi, Jiaqi Huang, Sean Humphray, Javier Jiménez, Nancy Keller, Hoda Khouri, Katsuhiko Kitamoto, Tetsuo Kobayashi, Sven Konzack, Resham Kulkarni, Toshitaka Kumagai, Anne Lafon, Jean-Paul Latgé, Weixi Li, Angela Lord, Charles Lu, William H. Majoros, Gregory S. May, Bruce L. Miller, Yasmin Mohamoud, Maria Molina, Michel Monod, Isabelle Mouyna, Stephanie Mulligan, Lee Murphy, Susan O'Neil, Ian Paulsen, Miguel A. Peñalva, Mihaela Pertea, Claire Price, Bethan L. Pritchard, Michael A. Quail, Ester Rabbinowitsch, Neil Rawlins, Marie-Adele Rajandream, Utz Reichard, Hubert Renauld, Geoffrey D. Robson, Santiago Rodriguez de Córdoba, Jose M. Rodríguez-Peña, Catherine M. Ronning, Simon Rutter, Steven L. Salzberg, Miguel Sanchez, Juan C. Sánchez-Ferrero, David Saunders, Kathy Seeger, Rob Squares, Steven Squares, Michio Takeuchi, Fredj Tekaia, Geoffrey Turner, Carlos R. Vazquez de Aldana, Janice Weidman, Owen White, John Woodward, Jae-Hyuk Yu, Claire Fraser, James E. Galagan, Kiyoshi Asai, Masayuki Machida, Neil Hall, Bart Barrell and David W. Denning

doi:10.1038/nature04572

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Naturejobs

Going global p503

International research consortium may promote freer exchange of ideas and personnel.

Paul Smaglik

doi:10.1038/439503a

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School's in for summer p504

Don't stack shelves in the precious break between terms, stack up your lab experience. Hannah Hoag studies the world of the summer intern.

Hannah Hoag

doi:10.1038/nj7075-504a

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Alan Hall, chairman, cell biology programme, Memorial Sloan-Kettering Cancer Center, New York p506

After switching to molecular biology and stumbling into cancer research, Alan Hall moves from Britain to New York.

Corie Lok

doi:10.1038/nj7075-506a

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Nanoscience factory p506

A user facility for nanoscientists opens this spring.

Paul Smaglik

doi:10.1038/nj7075-506b

Full Text | PDF (129K)

Taking to the air p506

Former Graduate Journal writer compares academia to the business world.

Philipp Angerer

doi:10.1038/nj7075-506c

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Futures

Panpsychism proved p508

Met with stony silence.

Rudy Rucker

doi:10.1038/439508a

Full Text | PDF (171K)