Access
To read this story in full you will need to login or make a payment (see right).
News and Views
Nature 439, 406-407 (26 January 2006) | doi:10.1038/439406a; Published online 25 January 2006
nature jobs
Regulatory Associate / Specialist-DRA-EGM_LATAM (Rest of World)
- Novartis Healthcare Private Limited
- Hyderabad, A.P. 500081 India
Endowed Associate Professorship
- University of Denver
- Denver, CO
DNA repair: Tails of histones lost
André Nussenzweig1 & Tanya Paull2
Abstract
A double-stranded break in DNA can profoundly destabilize a cell's genome. But how does the cell recognize the damage and halt division until it can be fixed? The answer lies in the proteins that package and unravel DNA.
DNA damage induces cell-cycle checkpoints that transiently arrest progression through the cell-division cycle. This delay gives the DNA-repair machinery sufficient time to fix genomic damage before the cell cycle resumes.
- André Nussenzweig is in the Experimental Immunology Branch, National Institutes of Health, Bethesda, Maryland 20892, USA.
Email: andre_nussenzweig@nih.gov - Tanya Paull is in the Department of Molecular Genetics and Microbiology, University of Texas at Austin, 1 University Station A5000, Austin, Texas 78712, USA.
Email: tpaull@icmb.utexas.edu
To read this story in full you will need to login or make a payment (see right).
MORE ARTICLES LIKE THIS
These links to content published by NPG are automatically generated.
NEWS AND VIEWS
Chromatin and DNA repair: the benefits of relaxationNature Cell Biology News and Views (01 Jan 2006)
At the end, remodeling leads to evictionNature Structural & Molecular Biology News and Views (01 Dec 2005)
See all 4 matches for News And ViewsRESEARCH
Mammalian SWI/SNF complexes facilitate DNA double-strand break repair by promoting γ-H2AX inductionThe EMBO Journal Article
Mammalian SWI/SNF complexes facilitate DNA double-strand break repair by promoting γ-H2AX inductionThe EMBO Journal Article (06 Sep 2006)
See all 10 matches for Research