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News and Views
Nature 439, 406-407 (26 January 2006) | doi:10.1038/439406a; Published online 25 January 2006
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DNA repair: Tails of histones lost
André Nussenzweig1 & Tanya Paull2
Abstract
A double-stranded break in DNA can profoundly destabilize a cell's genome. But how does the cell recognize the damage and halt division until it can be fixed? The answer lies in the proteins that package and unravel DNA.
DNA damage induces cell-cycle checkpoints that transiently arrest progression through the cell-division cycle. This delay gives the DNA-repair machinery sufficient time to fix genomic damage before the cell cycle resumes.
- André Nussenzweig is in the Experimental Immunology Branch, National Institutes of Health, Bethesda, Maryland 20892, USA.
Email: andre_nussenzweig@nih.gov - Tanya Paull is in the Department of Molecular Genetics and Microbiology, University of Texas at Austin, 1 University Station A5000, Austin, Texas 78712, USA.
Email: tpaull@icmb.utexas.edu
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