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Nature 438, 747-749 (8 December 2005) | doi:10.1038/438747a; Published online 7 December 2005
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Cell biology: Relays at the membrane
Roel Nusse1
Abstract
The Wnt signalling pathway is a major route by which the cell conveys information from its exterior to the nucleus. A gap in the sequence of signalling proteins has now been filled.
The process of signal transduction allows a cell to receive messages from its environment and transfer this signal from the membrane through the cytoplasm and into the nucleus. Here the signal alters the expression of the various genes that contribute to the cell's response.
- Roel Nusse is in the Howard Hughes Medical Institute, Department of Developmental Biology, Beckman Center, Stanford University, Stanford, California 94305-5329, USA.
Email: rnusse@stanford.edu
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