Abstract
Wilson discusses the avidity of the lymph-node T-cell clones we described1 that recognize the insulin A1–15 fragment. He questions whether large enough concentrations of insulin would be available in situ for antigenic stimulation of T cells2, given the amount of peptide required to stimulate the clones and their degree of responsiveness.
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Hafler, D., Kent, S., Chen, Y. et al. Insulin auto-antigenicity in type 1 diabetes (Reply). Nature 438, E5–E6 (2005). https://doi.org/10.1038/nature04424
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DOI: https://doi.org/10.1038/nature04424
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