Distinguishing self from non-self is the underlying basis of immunity. Intriguingly, the genetic system that governs a natural process akin to tissue transplantation in vertebrates has been characterized in an invertebrate.
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Litman, G. Colonial match and mismatch. Nature 438, 437–439 (2005). https://doi.org/10.1038/438437a
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DOI: https://doi.org/10.1038/438437a