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Nature 438, 436-437 (24 November 2005) | doi:10.1038/438436b; Published online 23 November 2005

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Obesity: Aquaporin enters the picture

Gema Frühbeck1

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The aquaporins are membrane channels that were originally identified as regulators of a cell's water balance. A member of the aquaporin family is now implicated as a central agent in controlling fat metabolism.

Mammals, like other organisms, have had to cope with feast and famine over evolutionary time. Hence the selection of genes that in times of plenty allow fat accumulation — principally in the form of triglycerides in fat cells — and in times of need promote the mobilization of those reserves.

  1. Gema Frühbeck is in the Department of Endocrinology, Clínica Universitaria, Universidad de Navarra, 31008 Pamplona, Spain.
    Email: gfruhbeck@unav.es

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RESEARCH

Fasting-induced increases in aquaporin 7 and adipose triglyceride lipase mRNA expression in adipose tissue are attenuated by peroxisome proliferator-activated receptor α deficiency

International Journal of Obesity Original Article