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Nature 437, 1241-1242 (27 October 2005) | doi:10.1038/4371241a; Published online 26 October 2005

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Genomics: Understanding human diversity

David B. Goldstein1 & Gianpiero L. Cavalleri1

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The first edition of a massive catalogue of human genetic variation is now complete. The long-term task is to translate these data into an understanding of the effects of that variation on human health.

When, as a medical student, the author W. Somerset Maugham could not find a nerve where it was supposed to be, his anatomy instructor uncovered the hidden nerve and explained that "the normal is the rarest thing in the world"1.

  1. David B. Goldstein and Gianpiero L. Cavalleri are at the Institute for Genome Sciences and Policy, Center for Population Genomics and Pharmacogenetics, Duke University, 103 Research Drive, DUMC Box 3471, Durham, North Carolina 27710, USA.
    Email: d.goldstein@duke.edu

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