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Nature 437, 631-632 (29 September 2005) | doi:10.1038/437631a; Published online 28 September 2005

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Systems biology: Deviations in mating

Avigdor Eldar1 & Michael Elowitz1

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Why do cells of the same type, grown in the same conditions, look and behave so differently? Studying fluctuations in a well-characterized genetic pathway in yeast hints at how such variation arises.

A glance in a microscope quickly convinces one that cells are strikingly diverse. Even when they share the same genome and are grown in the same environment, individual cells differ in size, shape and response to stimuli.

  1. Avigdor Eldar and Michael Elowitz are in the Division of Biology and Department of Applied Physics, California Institute of Technology, Pasadena, California 91125, USA.
    Email: melowitz@caltech.edu

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