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Nature 437, 491-493 (22 September 2005) | doi:10.1038/437491a; Published online 21 September 2005
Open Innovation Challenges
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Direct Molecular Detection of Proteins and Nucleic Acids
This Challenge is looking for novel approaches to protein and nucleic acid detection. This is an Id...
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Methods of Modeling Adaptation in Populations
The analysis of adaptation with a population is a frequently encountered computational modeling scen...
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PhD or Postdoctoral Fellow: DFT Calculations in Materials Science
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- Alliance Institute of Advanced Pharmacy and Health Sciences
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Pharmaceuticals: A new grammar for drug discovery
Mark C. Fishman1 & Jeffery A. Porter1
Abstract
To realize the potential of the genome for identifying candidate drugs we must move beyond individual genes and proteins. The signalling pathways in cells provide the right level for such analyses.
Drug discovery is a tough business scientifically, the traditional steps taking nearly a decade. In this article we are concerned only with the very beginning of the process, the identification of a target for a new drug.
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