How much and what kind of information is required to fold a chain of amino acids into a functioning protein? It seems the problem may not be as daunting as once thought — the solution is in the coevolution data.
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Kelly, J. Form and function instructions. Nature 437, 486–487 (2005). https://doi.org/10.1038/437486a
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DOI: https://doi.org/10.1038/437486a