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Nature 437, 486-487 (22 September 2005) | doi:10.1038/437486a; Published online 21 September 2005
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Structural biology: Form and function instructions
Jeffery W. Kelly1
Abstract
How much and what kind of information is required to fold a chain of amino acids into a functioning protein? It seems the problem may not be as daunting as once thought — the solution is in the coevolution data.
The linear sequence of amino acids in a protein specifies its final three-dimensional structure and function1. But what molecular information is necessary and sufficient to specify protein form and function?
- Jeffery W. Kelly is in the Department of Chemistry, The Scripps Research Institute, La Jolla, California 92037, USA.
Email: jkelly@scripps.edu
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RESEARCH
Evolutionary information for specifying a protein foldNature Article (22 Sep 2005)
Natural-like function in artificial WW domainsNature Letters to Editor (22 Sep 2005)
