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News and Views
Nature 437, 201-202 (8 September 2005) | doi:10.1038/437201a; Published online 7 September 2005
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Scientist, Recombinant Protein Expression
- Novo Nordisk Foundation Center for Protein Research, University of Copenhagen
- Copenhagen 2200 Denmark
Analytical Organic Chemist / Phytochemist
- Cambridge Theranostics Ltd
- Cambridge United Kingdom
Synthetic chemistry: Glycosylation with a twist
Sabine L. Flitsch1
Abstract
Nature has a whole battery of dedicated enzymes to make the complex links between sugar rings — how can synthetic chemists compete? An ingenious approach fills a big gap in the synthetic tool-kit.
Sugars can be linked together in a number of different ways to create chains. The resulting glycoside molecules have numerous biological functions, both by themselves and particularly when attached to proteins and lipids.
- Sabine L. Flitsch is in the School of Chemistry and the Manchester Interdisciplinary Biocentre, University of Manchester, Oxford Road, Manchester M13 9PL, UK.
Email: sabine.flitsch@manchester.ac.uk
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