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Nature 436, 1096-1097 (25 August 2005) | doi:10.1038/4361096a; Published online 24 August 2005
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Computational Chemist
- Pfizer
- Sandwich, Kent, United Kingdom
Senior Scientist, Chemoinformatics
- Novo Nordisk Foundation Center for Protein Research, University of Copenhagen
- Copenhagen 2200 Denmark
Biological chemistry: Enzymes in focus
Romas Kazlauskas1
Abstract
The technique of directed evolution creates thousands of mutant enzymes from a single original. A new approach helps to search for variants that have an increased range of substrates — and can thus be used for organic synthesis.
Protein catalysts, or enzymes, are useful in organic synthesis largely because they can accept substrates other than their natural ones. Yet they can still distinguish subtle differences in shape between substrates — a characteristic known as stereoselectivity.
- Romas Kazlauskas is in the Department of Biochemistry, Molecular Biology and Biophysics, University of Minnesota, 1479 Gortner Avenue, Saint Paul, Minnesota 55108, USA.
Email: rjk@umn.edu
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