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Nature 436, 961-966 (18 August 2005) | doi:10.1038/nature04081; Published online 17 August 2005
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review article Prospects for a vaccine against the hepatitis C virus
Michael Houghton1 & Sergio Abrignani2
Abstract
The recent discovery of natural immunity to the hepatitis C virus and vaccine efficacy in the chimpanzee challenge model has allowed optimism about the development of at least a partly effective vaccine against this heterogeneous pathogen that is responsible for much of the chronic liver disease around the world. The immune systems of some infected individuals can spontaneously clear the virus, whereas other people need treatment with antivirals that work partly by stimulating humoral and cellular immune responses. Therefore, therapeutic vaccine strategies are also being pursued to improve treatment outcome.
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