Table of contents
Volume 436 Number 7051 pp603-752
Editorials
Station at a crossroads p603
Frank international discussions need to start immediately if anything is to be salvaged from the space station, whose completion currently relies on the ailing space shuttle.
doi:10.1038/436603a
Count themselves lucky p603
Mathematicians might think they have an image problem, but the public holds them in great esteem.
doi:10.1038/436603b
A dog's life p604
The first cloned dog was born at some cost, and there needn't be many more.
doi:10.1038/436604a
News
Senator boosts chances of stem-cell reform p608
Majority leader changes mind over funding rules.
Erika Check
doi:10.1038/436608a
More falling foam puts shuttle programme in serious doubt p608
Fleet grounded as NASA seeks solutions.
Mark Peplow
doi:10.1038/436608b
Bone cells linked to creation of fresh eggs in mammals p609
Hackles rise over claims on ovulation.
Claire Ainsworth
doi:10.1038/436609a
Sidelines p610
doi:10.1038/436610a
Shadow hangs over research into Japan's bomb victims p610
Radiation foundation faces uncertain future.
Tom Simonite
doi:10.1038/436610b
Mars orbiter ready to scout for future landing sites as NASA looks ahead p613
Launch date approaches for next mission to red planet.
Tony Reichhardt
doi:10.1038/436613a
Drugs could head off a flu pandemic — but only if we respond fast enough p614
Models show how spread of disease might be stopped.
Declan Butler
doi:10.1038/436614a
See also: Editor's summary
US energy bill pushes research but fails to cut consumption p615
Critics slam policy as compromise rather than strategy.
Emma Marris
doi:10.1038/436615a
News Features
Pluto voyage: A man with a mission p618
In 2015, Pluto will welcome its first visitor, a robot named New Horizons. Amanda Haag meets the planetary scientist who nursed the mission through its darkest days.
doi:10.1038/436618a
See also: Editor's summary
Malyasian biotechnology: The valley of ghosts p620
While other Asian tigers are roaring ahead in biotechnology, Malaysia's BioValley is going nowhere fast. David Cyranoski asks what went wrong.
doi:10.1038/436620a
Dramatizing maths: What's the plot? p622
Can mathematicians learn from the narrative approaches of the writers who popularize and dramatize their work? Sarah Tomlin is on the story.
doi:10.1038/436622a
Business
Fatal attraction p624
Oxford Instruments has paid dear for its bold efforts to stretch the boundaries of magnet performance, as Andrea Chipman reports.
doi:10.1038/436624a
In Brief p625
doi:10.1038/436625a
Market Watch p625
doi:10.1038/436625b
Correspondence
China building teams to tackle public-health crises p626
Yu Wang, Guang Zeng and Robert E. Fontaine
doi:10.1038/436626a
Education and penalties are key to tackling misconduct p626
Kai Wang
doi:10.1038/436626b
Academia's 'misconduct' is acceptable to industry p626
Ian Taylor
doi:10.1038/436626c
Misconduct: pressure to achieve corrodes ideals p626
Lutz P. Breitling
doi:10.1038/436626d
Books and Arts
Cool is not enough p627
There's more to life than the second law of thermodynamics.
J. Doyne Farmer reviews Into the Cool: Energy Flow, Thermodynamics and Life by Eric D. Schneider and Dorion Sagan
doi:10.1038/436627a
Russia's secret weapons p628
Jens H. Kuhn, Milton Leitenberg and Raymond A. Zilinskas review Biological Espionage: Special Operations of the Soviet and Russian Foreign Intelligence Services in the West by Alexander Kouzminov
doi:10.1038/436628a
Science in culture: Surface tensions p629
A reinterpretation, using damaged photographs, of a failed attempt to fly to the North Pole.
Colin Martin
doi:10.1038/436629a
News and Views
Geochemistry: On the Moon as it was on Earth p631
Does the Moon's surface contain an archive of the early history of Earth? According to an intriguing idea, based on recently published analyses of lunar soils, it might do — and the proposal can be tested.
Bernard Marty
doi:10.1038/436631a
See also: Editor's summary
Neurobiology: Getting axons going p632
Neurons extend one long axon, through which they transmit electrical impulses to other cells in the nervous system. Surprisingly, it seems that where the axon forms is determined entirely within the neuron.
Juergen A. Knoblich
doi:10.1038/436632a
Quantum Information: Putting certainty in the bank p633
A new way to manipulate quantum states resolves a long-standing conundrum about who knows what, and when and how, in the quantum world. The result is, as one has come to expect, startling and counterintuitive.
Patrick Hayden
doi:10.1038/436633a
50 & 100 years ago p634
doi:10.1038/436634a
Ecology: Neutral theory tested by birds p635
A continental-scale analysis of habitat and bird distribution in South America provides the latest challenge for neutral theory — a controversial idea in ecology about what determines the make-up of communities.
Annette Ostling
doi:10.1038/436635a
Cancer: Crime and punishment p636
Cellular senescence stops the growth of cells. This process, first glimpsed in cell culture, is now confirmed by in vivo evidence as a vital mechanism that constrains the malignant progression of many tumours.
Norman E. Sharpless and Ronald A. DePinho
doi:10.1038/436636a
See also: Editor's summary
Earth science: Trouble under Tonga? p637
Earthquakes occur in cool, foundering tectonic plates deep within the Earth. But seismic data from the southwestern Pacific indicate that the minerals that make up the plates at depth don't behave as if they are cool.
George Helffrich
doi:10.1038/436637a
Cell biology: Without a raft p638
The spatial organization of signalling proteins in the cell membrane is often ascribed to lipid-based 'rafts'. But single-molecule tracking reveals that such organization probably arises by protein–protein interactions.
Ben Nichols
doi:10.1038/436638a
Brief Communications
Dogs cloned from adult somatic cells p641
Byeong Chun Lee, Min Kyu Kim, Goo Jang, Hyun Ju Oh, Fibrianto Yuda, Hye Jin Kim, M. Hossein Shamim, Jung Ju Kim, Sung Keun Kang, Gerald Schatten and Woo Suk Hwang
doi:10.1038/436641a
First paragraph | Full Text | PDF (708K) | Supplementary information
See also: Editor's summary
Tumour biology: Senescence in premalignant tumours p642
Manuel Collado, Jesús Gil, Alejo Efeyan, Carmen Guerra, Alberto J. Schuhmacher, Marta Barradas, Alberto Benguría, Angel Zaballos, Juana M. Flores, Mariano Barbacid, David Beach and Manuel Serrano
doi:10.1038/436642a
First paragraph | Full Text | PDF (303K) | Supplementary information
See also: Editor's summary
Feature
What Henslow taught Darwin p643
How a herbarium helped to lay the foundations of evolutionary thinking.
David Kohn, Gina Murrell, John Parker and Mark Whitehorn
doi:10.1038/436643a
See also: Editor's summary
Review
A possible unifying principle for mechanosensation p647
Ching Kung
doi:10.1038/nature03896
Abstract | Full Text | PDF (497K)
See also: Editor's summary
Articles
Terrestrial nitrogen and noble gases in lunar soils p655
M. Ozima, K. Seki, N. Terada, Y. N. Miura, F. A. Podosek and H. Shinagawa
doi:10.1038/nature03929
Abstract | Full Text | PDF (316K)
See also: Editor's summary | News and Views by Marty
Oncogene-induced senescence as an initial barrier in lymphoma development p660
Melanie Braig, Soyoung Lee, Christoph Loddenkemper, Cornelia Rudolph, Antoine H.F.M. Peters, Brigitte Schlegelberger, Harald Stein, Bernd Dörken, Thomas Jenuwein and Clemens A. Schmitt
doi:10.1038/nature03841
Abstract | Full Text | PDF (510K) | Supplementary information
See also: Editor's summary | News and Views by Sharpless & DePinho
Letters
The obscuration by dust of most of the growth of supermassive black holes p666
Alejo Martínez-Sansigre, Steve Rawlings, Mark Lacy, Dario Fadda, Francine R. Marleau, Chris Simpson, Chris J. Willott and Matt J. Jarvis
doi:10.1038/nature03829
First paragraph | Full Text | PDF (202K) | Supplementary information
See also: Editor's summary
No oceans on Titan from the absence of a near-infrared specular reflection p670
R. A. West, M. E. Brown, S. V. Salinas, A. H. Bouchez and H. G. Roe
doi:10.1038/nature03824
First paragraph | Full Text | PDF (360K)
See also: Editor's summary
Partial quantum information p673
Micha
Horodecki,
Jonathan Oppenheim
and
Andreas Winter
doi:10.1038/nature03909
First paragraph | Full Text | PDF (160K)
See also: News and Views by Hayden
Measurement of the conductance of single conjugated molecules p677
Tali Dadosh, Yoav Gordin, Roman Krahne, Ilya Khivrich, Diana Mahalu, Veronica Frydman, Joseph Sperling, Amir Yacoby and Israel Bar-Joseph
doi:10.1038/nature03898
First paragraph | Full Text | PDF (419K) | Supplementary information
Stability of the Larsen B ice shelf on the Antarctic Peninsula during the Holocene epoch p681
Eugene Domack, Diana Duran, Amy Leventer, Scott Ishman, Sarah Doane, Scott McCallum, David Amblas, Jim Ring, Robert Gilbert and Michael Prentice
doi:10.1038/nature03908
First paragraph | Full Text | PDF (545K) | Supplementary information
See also: Editor's summary
Increasing destructiveness of tropical cyclones over the past 30 years p686
Kerry Emanuel
doi:10.1038/nature03906
First paragraph | Full Text | PDF (184K) | Supplementary information
See also: Editor's summary
Earthquake slip weakening and asperities explained by thermal pressurization p689
Christopher A. J. Wibberley and Toshihiko Shimamoto
doi:10.1038/nature03901
First paragraph | Full Text | PDF (358K)
See also: Editor's summary
Dental microwear texture analysis shows within-species diet variability in fossil hominins p693
Robert S. Scott, Peter S. Ungar, Torbjorn S. Bergstrom, Christopher A. Brown, Frederick E. Grine, Mark F. Teaford and Alan Walker
doi:10.1038/nature03822
First paragraph | Full Text | PDF (401K)
See also: Editor's summary
Refractory periods and climate forcing in cholera dynamics p696
Katia Koelle, Xavier Rodó, Mercedes Pascual, Md. Yunus and Golam Mostafa
doi:10.1038/nature03820
First paragraph | Full Text | PDF (352K) | Supplementary information
See also: Editor's summary
Genetic interactions between polymorphisms that affect gene expression in yeast p701
Rachel B. Brem, John D. Storey, Jacqueline Whittle and Leonid Kruglyak
doi:10.1038/nature03865
First paragraph | Full Text | PDF (211K) | Supplementary information
Centrosome localization determines neuronal polarity p704
Froylan Calderon de Anda, Giulia Pollarolo, Jorge Santos Da Silva, Paola G. Camoletto, Fabian Feiguin and Carlos G. Dotti
doi:10.1038/nature03811
First paragraph | Full Text | PDF (353K) | Supplementary information
See also: News and Views by Knoblich
Licensing of natural killer cells by host major histocompatibility complex class I molecules p709
Sungjin Kim, Jennifer Poursine-Laurent, Steven M. Truscott, Lonnie Lybarger, Yun-Jeong Song, Liping Yang, Anthony R. French, John B. Sunwoo, Suzanne Lemieux, Ted H. Hansen and Wayne M. Yokoyama
doi:10.1038/nature03847
First paragraph | Full Text | PDF (494K) | Supplementary information
The origin of the naked grains of maize p714
Huai Wang, Tina Nussbaum-Wagler, Bailin Li, Qiong Zhao, Yves Vigouroux, Marianna Faller, Kirsten Bomblies, Lewis Lukens and John F. Doebley
doi:10.1038/nature03863
First paragraph | Full Text | PDF (647K) | Supplementary information
See also: Editor's summary
BRAFE600-associated senescence-like cell cycle arrest of human naevi p720
Chrysiis Michaloglou, Liesbeth C. W. Vredeveld, Maria S. Soengas, Christophe Denoyelle, Thomas Kuilman, Chantal M. A. M. van der Horst, Donné M. Majoor, Jerry W. Shay, Wolter J. Mooi and Daniel S. Peeper
doi:10.1038/nature03890
First paragraph | Full Text | PDF (578K) | Supplementary information
See also: Editor's summary | News and Views by Sharpless & DePinho
Crucial role of p53-dependent cellular senescence in suppression of Pten-deficient tumorigenesis p725
Zhenbang Chen, Lloyd C. Trotman, David Shaffer, Hui-Kuan Lin, Zohar A. Dotan, Masaru Niki, Jason A. Koutcher, Howard I. Scher, Thomas Ludwig, William Gerald, Carlos Cordon-Cardo and Pier Paolo Pandolfi
doi:10.1038/nature03918
First paragraph | Full Text | PDF (687K) | Supplementary information
See also: Editor's summary | News and Views by Sharpless & DePinho
A cytokinesis furrow is positioned by two consecutive signals p731
Henrik Bringmann and Anthony A Hyman
doi:10.1038/nature03823
First paragraph | Full Text | PDF (398K) | Supplementary information
Transcription of mammalian messenger RNAs by a nuclear RNA polymerase of mitochondrial origin p735
Julia E. Kravchenko, Igor B. Rogozin, Eugene V. Koonin and Peter M. Chumakov
doi:10.1038/nature03848
First paragraph | Full Text | PDF (392K) | Supplementary information
TRBP recruits the Dicer complex to Ago2 for microRNA processing and gene silencing p740
Thimmaiah P. Chendrimada, Richard I. Gregory, Easwari Kumaraswamy, Jessica Norman, Neil Cooch, Kazuko Nishikura and Ramin Shiekhattar
doi:10.1038/nature03868
First paragraph | Full Text | PDF (403K)
Naturejobs
ProspectYou've got to laugh... p745
Grad students get connected through comics
Paul Smaglik
doi:10.1038/nj7051-745a
Careers and Recruitment
An individual approach p746
Reduced side effects and more effective therapies are some of the benefits promised by pharmacogenomics. But to reach these goals industry will have to marshall a broad range of skills, as Ricki Lewis explains.
Ricki Lewis
doi:10.1038/nj7051-746a
Special Report
On firm foundations p748
Flexible and relatively unfettered, non-profit foundations are able to boldly go into areas of research funding often untouched by public bodies, says Helen Gavaghan.
Helen Gavaghan
doi:10.1038/nj7051-748a
Futures
Pigs on the wing p752
Aurorae in the sky with diamonds, just $10.99 (exc. tax).
K. Erik Ziemelis
doi:10.1038/436752a
