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Editorials

Station at a crossroads p603

Frank international discussions need to start immediately if anything is to be salvaged from the space station, whose completion currently relies on the ailing space shuttle.

doi:10.1038/436603a


Count themselves lucky p603

Mathematicians might think they have an image problem, but the public holds them in great esteem.

doi:10.1038/436603b


A dog's life p604

The first cloned dog was born at some cost, and there needn't be many more.

doi:10.1038/436604a


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Research Highlights

Research highlights p606

doi:10.1038/436606a


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News

Senator boosts chances of stem-cell reform p608

Majority leader changes mind over funding rules.

Erika Check

doi:10.1038/436608a


More falling foam puts shuttle programme in serious doubt p608

Fleet grounded as NASA seeks solutions.

Mark Peplow

doi:10.1038/436608b


Bone cells linked to creation of fresh eggs in mammals p609

Hackles rise over claims on ovulation.

Claire Ainsworth

doi:10.1038/436609a


Sidelines p610

doi:10.1038/436610a


Shadow hangs over research into Japan's bomb victims p610

Radiation foundation faces uncertain future.

Tom Simonite

doi:10.1038/436610b


Mars orbiter ready to scout for future landing sites as NASA looks ahead p613

Launch date approaches for next mission to red planet.

Tony Reichhardt

doi:10.1038/436613a


Drugs could head off a flu pandemic — but only if we respond fast enough p614

Models show how spread of disease might be stopped.

Declan Butler

doi:10.1038/436614a

See also: Editor's summary


US energy bill pushes research but fails to cut consumption p615

Critics slam policy as compromise rather than strategy.

Emma Marris

doi:10.1038/436615a


News in brief p616

doi:10.1038/436616a


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News Features

Pluto voyage:  A man with a mission p618

In 2015, Pluto will welcome its first visitor, a robot named New Horizons. Amanda Haag meets the planetary scientist who nursed the mission through its darkest days.

doi:10.1038/436618a

See also: Editor's summary


Malyasian biotechnology:  The valley of ghosts p620

While other Asian tigers are roaring ahead in biotechnology, Malaysia's BioValley is going nowhere fast. David Cyranoski asks what went wrong.

doi:10.1038/436620a


Dramatizing maths:  What's the plot? p622

Can mathematicians learn from the narrative approaches of the writers who popularize and dramatize their work? Sarah Tomlin is on the story.

doi:10.1038/436622a


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Business

Fatal attraction p624

Oxford Instruments has paid dear for its bold efforts to stretch the boundaries of magnet performance, as Andrea Chipman reports.

doi:10.1038/436624a


In Brief p625

doi:10.1038/436625a


Market Watch p625

doi:10.1038/436625b


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Correspondence

China building teams to tackle public-health crises p626

Yu Wang, Guang Zeng and Robert E. Fontaine

doi:10.1038/436626a


Education and penalties are key to tackling misconduct p626

Kai Wang

doi:10.1038/436626b


Academia's 'misconduct' is acceptable to industry p626

Ian Taylor

doi:10.1038/436626c


Misconduct: pressure to achieve corrodes ideals p626

Lutz P. Breitling

doi:10.1038/436626d


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Books and Arts

Cool is not enough p627

There's more to life than the second law of thermodynamics.

J. Doyne Farmer reviews Into the Cool: Energy Flow, Thermodynamics and Life by Eric D. Schneider and Dorion Sagan

doi:10.1038/436627a


Russia's secret weapons p628

Jens H. Kuhn, Milton Leitenberg and Raymond A. Zilinskas review Biological Espionage: Special Operations of the Soviet and Russian Foreign Intelligence Services in the West by Alexander Kouzminov

doi:10.1038/436628a


Science in culture: Surface tensions p629

A reinterpretation, using damaged photographs, of a failed attempt to fly to the North Pole.

Colin Martin

doi:10.1038/436629a


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News and Views

Geochemistry:  On the Moon as it was on Earth p631

Does the Moon's surface contain an archive of the early history of Earth? According to an intriguing idea, based on recently published analyses of lunar soils, it might do — and the proposal can be tested.

Bernard Marty

doi:10.1038/436631a

See also: Editor's summary


Neurobiology:  Getting axons going p632

Neurons extend one long axon, through which they transmit electrical impulses to other cells in the nervous system. Surprisingly, it seems that where the axon forms is determined entirely within the neuron.

Juergen A. Knoblich

doi:10.1038/436632a


Quantum Information:  Putting certainty in the bank p633

A new way to manipulate quantum states resolves a long-standing conundrum about who knows what, and when and how, in the quantum world. The result is, as one has come to expect, startling and counterintuitive.

Patrick Hayden

doi:10.1038/436633a


50 & 100 years ago p634

doi:10.1038/436634a


Ecology:  Neutral theory tested by birds p635

A continental-scale analysis of habitat and bird distribution in South America provides the latest challenge for neutral theory — a controversial idea in ecology about what determines the make-up of communities.

Annette Ostling

doi:10.1038/436635a


Cancer:  Crime and punishment p636

Cellular senescence stops the growth of cells. This process, first glimpsed in cell culture, is now confirmed by in vivo evidence as a vital mechanism that constrains the malignant progression of many tumours.

Norman E. Sharpless and Ronald A. DePinho

doi:10.1038/436636a

See also: Editor's summary


Earth science:  Trouble under Tonga? p637

Earthquakes occur in cool, foundering tectonic plates deep within the Earth. But seismic data from the southwestern Pacific indicate that the minerals that make up the plates at depth don't behave as if they are cool.

George Helffrich

doi:10.1038/436637a


Cell biology:  Without a raft p638

The spatial organization of signalling proteins in the cell membrane is often ascribed to lipid-based 'rafts'. But single-molecule tracking reveals that such organization probably arises by protein–protein interactions.

Ben Nichols

doi:10.1038/436638a


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Brief Communications

Dogs cloned from adult somatic cells p641

Byeong Chun Lee, Min Kyu Kim, Goo Jang, Hyun Ju Oh, Fibrianto Yuda, Hye Jin Kim, M. Hossein Shamim, Jung Ju Kim, Sung Keun Kang, Gerald Schatten and Woo Suk Hwang

doi:10.1038/436641a

See also: Editor's summary


Tumour biology:  Senescence in premalignant tumours p642

Manuel Collado, Jesús Gil, Alejo Efeyan, Carmen Guerra, Alberto J. Schuhmacher, Marta Barradas, Alberto Benguría, Angel Zaballos, Juana M. Flores, Mariano Barbacid, David Beach and Manuel Serrano

doi:10.1038/436642a

See also: Editor's summary


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Feature

What Henslow taught Darwin p643

How a herbarium helped to lay the foundations of evolutionary thinking.

David Kohn, Gina Murrell, John Parker and Mark Whitehorn

doi:10.1038/436643a

See also: Editor's summary


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Review

A possible unifying principle for mechanosensation p647

Ching Kung

doi:10.1038/nature03896

See also: Editor's summary


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Articles

Terrestrial nitrogen and noble gases in lunar soils p655

M. Ozima, K. Seki, N. Terada, Y. N. Miura, F. A. Podosek and H. Shinagawa

doi:10.1038/nature03929

See also: Editor's summary | News and Views by Marty


Oncogene-induced senescence as an initial barrier in lymphoma development p660

Melanie Braig, Soyoung Lee, Christoph Loddenkemper, Cornelia Rudolph, Antoine H.F.M. Peters, Brigitte Schlegelberger, Harald Stein, Bernd Dörken, Thomas Jenuwein and Clemens A. Schmitt

doi:10.1038/nature03841

See also: Editor's summary | News and Views by Sharpless & DePinho


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Letters

The obscuration by dust of most of the growth of supermassive black holes p666

Alejo Martínez-Sansigre, Steve Rawlings, Mark Lacy, Dario Fadda, Francine R. Marleau, Chris Simpson, Chris J. Willott and Matt J. Jarvis

doi:10.1038/nature03829

See also: Editor's summary


No oceans on Titan from the absence of a near-infrared specular reflection p670

R. A. West, M. E. Brown, S. V. Salinas, A. H. Bouchez and H. G. Roe

doi:10.1038/nature03824

See also: Editor's summary


Partial quantum information p673

Michal stroke Horodecki, Jonathan Oppenheim and Andreas Winter

doi:10.1038/nature03909

See also: News and Views by Hayden


Measurement of the conductance of single conjugated molecules p677

Tali Dadosh, Yoav Gordin, Roman Krahne, Ilya Khivrich, Diana Mahalu, Veronica Frydman, Joseph Sperling, Amir Yacoby and Israel Bar-Joseph

doi:10.1038/nature03898


Stability of the Larsen B ice shelf on the Antarctic Peninsula during the Holocene epoch p681

Eugene Domack, Diana Duran, Amy Leventer, Scott Ishman, Sarah Doane, Scott McCallum, David Amblas, Jim Ring, Robert Gilbert and Michael Prentice

doi:10.1038/nature03908

See also: Editor's summary


Increasing destructiveness of tropical cyclones over the past 30 years p686

Kerry Emanuel

doi:10.1038/nature03906

See also: Editor's summary


Earthquake slip weakening and asperities explained by thermal pressurization p689

Christopher A. J. Wibberley and Toshihiko Shimamoto

doi:10.1038/nature03901

See also: Editor's summary


Dental microwear texture analysis shows within-species diet variability in fossil hominins p693

Robert S. Scott, Peter S. Ungar, Torbjorn S. Bergstrom, Christopher A. Brown, Frederick E. Grine, Mark F. Teaford and Alan Walker

doi:10.1038/nature03822

See also: Editor's summary


Refractory periods and climate forcing in cholera dynamics p696

Katia Koelle, Xavier Rodó, Mercedes Pascual, Md. Yunus and Golam Mostafa

doi:10.1038/nature03820

See also: Editor's summary


Genetic interactions between polymorphisms that affect gene expression in yeast p701

Rachel B. Brem, John D. Storey, Jacqueline Whittle and Leonid Kruglyak

doi:10.1038/nature03865


Centrosome localization determines neuronal polarity p704

Froylan Calderon de Anda, Giulia Pollarolo, Jorge Santos Da Silva, Paola G. Camoletto, Fabian Feiguin and Carlos G. Dotti

doi:10.1038/nature03811

See also: News and Views by Knoblich


Licensing of natural killer cells by host major histocompatibility complex class I molecules p709

Sungjin Kim, Jennifer Poursine-Laurent, Steven M. Truscott, Lonnie Lybarger, Yun-Jeong Song, Liping Yang, Anthony R. French, John B. Sunwoo, Suzanne Lemieux, Ted H. Hansen and Wayne M. Yokoyama

doi:10.1038/nature03847


The origin of the naked grains of maize p714

Huai Wang, Tina Nussbaum-Wagler, Bailin Li, Qiong Zhao, Yves Vigouroux, Marianna Faller, Kirsten Bomblies, Lewis Lukens and John F. Doebley

doi:10.1038/nature03863

See also: Editor's summary


BRAFE600-associated senescence-like cell cycle arrest of human naevi p720

Chrysiis Michaloglou, Liesbeth C. W. Vredeveld, Maria S. Soengas, Christophe Denoyelle, Thomas Kuilman, Chantal M. A. M. van der Horst, Donné M. Majoor, Jerry W. Shay, Wolter J. Mooi and Daniel S. Peeper

doi:10.1038/nature03890

See also: Editor's summary | News and Views by Sharpless & DePinho


Crucial role of p53-dependent cellular senescence in suppression of Pten-deficient tumorigenesis p725

Zhenbang Chen, Lloyd C. Trotman, David Shaffer, Hui-Kuan Lin, Zohar A. Dotan, Masaru Niki, Jason A. Koutcher, Howard I. Scher, Thomas Ludwig, William Gerald, Carlos Cordon-Cardo and Pier Paolo Pandolfi

doi:10.1038/nature03918

See also: Editor's summary | News and Views by Sharpless & DePinho


A cytokinesis furrow is positioned by two consecutive signals p731

Henrik Bringmann and Anthony A Hyman

doi:10.1038/nature03823


Transcription of mammalian messenger RNAs by a nuclear RNA polymerase of mitochondrial origin p735

Julia E. Kravchenko, Igor B. Rogozin, Eugene V. Koonin and Peter M. Chumakov

doi:10.1038/nature03848


TRBP recruits the Dicer complex to Ago2 for microRNA processing and gene silencing p740

Thimmaiah P. Chendrimada, Richard I. Gregory, Easwari Kumaraswamy, Jessica Norman, Neil Cooch, Kazuko Nishikura and Ramin Shiekhattar

doi:10.1038/nature03868


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Naturejobs

Prospect

You've got to laugh... p745

Grad students get connected through comics

Paul Smaglik

doi:10.1038/nj7051-745a


Careers and Recruitment

An individual approach p746

Reduced side effects and more effective therapies are some of the benefits promised by pharmacogenomics. But to reach these goals industry will have to marshall a broad range of skills, as Ricki Lewis explains.

Ricki Lewis

doi:10.1038/nj7051-746a


Special Report

On firm foundations p748

Flexible and relatively unfettered, non-profit foundations are able to boldly go into areas of research funding often untouched by public bodies, says Helen Gavaghan.

Helen Gavaghan

doi:10.1038/nj7051-748a


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Futures

Pigs on the wing p752

Aurorae in the sky with diamonds, just $10.99 (exc. tax).

K. Erik Ziemelis

doi:10.1038/436752a


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