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News and Views
Nature 436, 468-469 (28 July 2005) | doi:10.1038/436468a; Published online 27 July 2005
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Cancer: One step at a time
David Mooney1
Abstract
Traditional chemotherapy kills tumour cells directly; some newer drugs work instead by cutting the tumour's blood supply. An innovative approach combines these strategies sequentially to pack a double whammy.
In 1971, Judah Folkman proposed that the progression of cancer might be halted by preventing tumours from recruiting new blood vessels (a process called angiogenesis) to provide them with oxygen and nutrients. Last year, this theory bore fruit with the approval by the US Food and Drug Administration of the first anti-angiogenic cancer treatment, Avastin (also known as bevacizumab)1.
- David Mooney is in the Division of Engineering and Applied Sciences, Harvard University, Cambridge, Massachusetts 02138, USA.
Email: mooneyd@deas.harvard.edu
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