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Nature 436, 337-338 (21 July 2005) | doi:10.1038/436337a; Published online 20 July 2005
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Metabolism: A is for adipokine
Deborah M. Muoio1 & Christopher B. Newgard1
Abstract
Adipokines are hormones that signal changes in fatty-tissue mass and energy status so as to control fuel usage. A fat-derived adipokine that binds to vitamin A provides a new link between obesity and insulin resistance.
The worldwide epidemic of obesity has been accompanied by a surge in the incidence of diabetes1. Normally, control of blood glucose levels depends on the efficient action of insulin, which stimulates uptake of glucose from the blood and slows its output from the liver.
- Deborah M. Muoio and Christopher B. Newgard are in the Sarah W. Stedman Nutrition and Metabolism Center, and the Departments of Pharmacology and Cancer Biology and of Medicine, Duke University Medical Center, Durham, North Carolina 27710, USA.
Email: newga002@mc.duke.edu
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