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Letter
Nature 435, 954-958 (16 June 2005) | doi:10.1038/nature03572; Received 4 February 2005; Accepted 23 March 2005; Published online 20 April 2005
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A common somitic origin for embryonic muscle progenitors and satellite cells
Jérôme Gros1, Marie Manceau1, Virginie Thomé1 & Christophe Marcelle1
- Laboratoire de Génétique et de Physiologie du Développement, Developmental Biology Institute of Marseille, CNRS UMR 6545, Université de la Méditerranée, Campus de Luminy, case 907, 13288 Marseille Cedex 09, France
Correspondence to: Christophe Marcelle1 Correspondence and requests for materials should be addressed to C.M. (Email: marcelle@ibdm.univ-mrs.fr).
Abstract
In the embryo and in the adult, skeletal muscle growth is dependent on the proliferation and the differentiation of muscle progenitors present within muscle masses. Despite the importance of these progenitors, their embryonic origin is unclear1, 2. Here we use electroporation of green fluorescent protein in chick somites3, video confocal microscopy analysis of cell movements, and quail–chick grafting experiments to show that the dorsal compartment of the somite, the dermomyotome, is the origin of a population of muscle progenitors that contribute to the growth of trunk muscles during embryonic and fetal life. Furthermore, long-term lineage analyses indicate that satellite cells, which are known progenitors of adult skeletal muscles4, derive from the same dermomyotome cell population. We conclude that embryonic muscle progenitors and satellite cells share a common origin that can be traced back to the dermomyotome.
- Laboratoire de Génétique et de Physiologie du Développement, Developmental Biology Institute of Marseille, CNRS UMR 6545, Université de la Méditerranée, Campus de Luminy, case 907, 13288 Marseille Cedex 09, France
Correspondence to: Christophe Marcelle1 Correspondence and requests for materials should be addressed to C.M. (Email: marcelle@ibdm.univ-mrs.fr).
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