Table of contents
Volume 435 Number 7038 pp1-128
In this issue (5 May 2005)
Also this week
Editorials
In pursuit of systems p1
The study of functioning groups of molecules is an important frontier of biology at reductionist and holistic levels. Central to the long-term goals of scientific research, it brings its own challenges of infrastructure and evaluation.
doi: 10.1038/435001a
Fear and rambling at NASA p1
The US space agency needs an injection of rationality.
doi: 10.1038/435001b
News
Pesticide results help China edge transgenic rice towards market p3
Genetically modified varieties promise health benefits for farmers.
David Cyranoski
doi: 10.1038/435003a
Academics stress licence threat to US science p4
Alarms ring over rules for foreign nationals and 'sensitive' equipment.
Geoff Brumfiel
doi: 10.1038/435004a
Hubble rescue mission gears up despite shuttle setback p4
Tony Reichhardt
doi: 10.1038/435004b
US bungled investigation into weapons research in Iraq p5
Innocent scientists detained while real culprits went free.
Jim Giles and Geoff Brumfiel
doi: 10.1038/435005a
Rethink on review leaves researchers out in the cold p5
US National Science Foundation asks universities to pre-screen grants.
Geoff Brumfiel
doi: 10.1038/435005b
Free genome databases finally defeat Celera p6
Pioneering firm completes switch from genomics to drugs.
Emma Marris
doi: 10.1038/435006a
Arctic trends scrutinized as chilly winter destroys ozone p6
Is climate change to blame for looming northern hole?
Quirin Schiermeier
doi: 10.1038/435006b
Hikes in surface ozone could suffocate crops p7
Photosynthesis threatened by rising air pollution.
Jim Giles
doi: 10.1038/435007a
News Features
Labs on a chip: Meet the stripped down rat p12
Are wafers of silicon that support cells cultured from vital organs the future of drug testing and toxicology? Roxanne Khamsi talks to the pioneers creating model animals — and humans — on a chip.
doi: 10.1038/435012a
See also: Editor's summary
Hotwire my heart p14
Growing numbers of people are being implanted with electronic devices that can automatically restart a failing heart. But have the risks and benefits been adequately assessed? Duncan Graham-Rowe investigates.
doi: 10.1038/435014a
Correspondence
Guidelines reduce the risk of brain-scan shock p17
Responsibility for research is separate from a centre's duty of care to MRI volunteers.
John D. Pickard and Jonathan H. Gillard
doi: 10.1038/435017a
DNA barcoding a useful tool for taxonomists p17
David E. Schindel and Scott E. Miller
doi: 10.1038/435017b
Debate to be had on best practice in mentoring p17
Alan Lord
doi: 10.1038/435017c
Spring Books
Gödel's universe p19
The legacy of one of the greatest thinkers of the twentieth century.
Martin Davis reviews Incompleteness: The Proof and Paradox of Kurt Gödel by Rebecca Goldstein and A World Without Time: The Forgotten Legacy of Gödel and Einstein by Palle Yourgrau
doi: 10.1038/435019a
See also: Editor's summary
The dark side of astronomy p20
Thanu Padmanabhan reviews Empire of the Stars: Friendship, Obsession and Betrayal in the Quest for Black Holes by Arthur I. Miller
doi: 10.1038/435020a
Destroying the zombic hunch p21
Susan Blackmore reviews Sweet Dreams: Philosophical Obstacles to a Science of Consciousness by Daniel C. Dennett
doi: 10.1038/435021a
Making progress? p23
Don Ihde reviews FAB: The Coming Revolution on Your Desktop — From Personal Computers to Personal Fabrication by Neil Gershenfeld
doi: 10.1038/435023a
Climbing the evolutionary tree p24
Peter Andrews reviews The Ape in the Tree: An Intellectual and Natural History of Proconsul by Alan Walker and Pat Shipman
doi: 10.1038/435024a
The evolution of scientific thinking p25
Rachel Wood reviews Reef Madness: Charles Darwin, Alexander Agassiz, and the Meaning of Coral by David Dobbs
doi: 10.1038/435025a
With the future in mind p27
John C. Marshall reviews The 21st-Century Brain: Explaining, Mending and Manipulating the Mind by Steven Rose
doi: 10.1038/435027a
Literature red in tooth and claw p28
Michel Raymond reviews Madame Bovary's Ovaries: A Darwinian Look at Literature by David P. Barash and Nanelle R. Barash
doi: 10.1038/435028a
News and Views
Evolutionary biology: Ghost of speciation past p29
Lurking in the rivers of Botswana are the remnants of a diverse flock of cichlid fishes, whose origins can be traced to a lake that vanished more than 2,000 years ago.
Thomas D. Kocher
doi: 10.1038/435029a
See also: Editor's summary
Developmental biology: Morphogens hitch a greasy ride p30
Morphogen proteins guide the development of many tissues in animals, but how are these insoluble proteins ferried around the body? A well-known group of lipid transporters might be the answer.
Richard S. Mann and Joaquim Culi
doi: 10.1038/435030a
100 and 50 years ago p31
doi: 10.1038/435031a
Planetary science: Saturn's retrograde renegade p33
Data from the Cassini−Huygens mission provide convincing evidence that the saturnian moon Phoebe formed elsewhere in the Solar System, and was only later captured by Saturn's gravitational pull.
J. Brad Dalton
doi: 10.1038/435033a
See also: Editor's summary
Reproductive biology: Fatty link to fertility p34
A short delay in the attachment of embryos to the wall of the womb during early pregnancy adversely affects later developmental processes. New evidence reinforces the need for lipids to regulate this event.
S. K. Dey
doi: 10.1038/435034a
See also: Editor's summary
Materials science: A hard look at glass p35
The topology of amorphous glasses has generally been considered only at the level of atoms and their nearest neighbours. A larger-scale view gives a fresh perspective on the structure and formation of these glasses.
Paul Madden
doi: 10.1038/435035a
Cell biology: Sterol sensor comes up for air p37
In one example of a feedback mechanism in mammals, cells switch cholesterol synthesis on or off depending on the availability of sterol. A rewired version of this pathway in yeast acts instead as an oxygen sensor.
Renee M. Garza and Randolph Y. Hampton
doi: 10.1038/435037a
Brief Communications
Botany: Specialized bird perch aids cross-pollination p41
A plant scores by providing an access point for visiting sunbirds to feed on its nectar.
Bruce Anderson, William W. Cole and Spencer C. H. Barrett
doi: 10.1038/435041a
First paragraph | Full Text | PDF (260K) | Supplementary information
Biochemistry: A cadmium enzyme from a marine diatom p42
Todd W. Lane, Mak A. Saito, Graham N. George, Ingrid J. Pickering, Roger C. Prince and François M. M. Morel
doi: 10.1038/435042a
First paragraph | Full Text | PDF (125K) | Supplementary information
Corrigendum p42
doi: 10.1038/435042b
Articles
The genome of the social amoeba Dictyostelium discoideum p43
L. Eichinger, J. A. Pachebat, G. Glöckner, M.-A. Rajandream, R. Sucgang, M. Berriman, J. Song, R. Olsen, K. Szafranski, Q. Xu, B. Tunggal, S. Kummerfeld, M. Madera, B. A. Konfortov, F. Rivero, A. T. Bankier, R. Lehmann, N. Hamlin, R. Davies, P. Gaudet, P. Fey, K. Pilcher, G. Chen, D. Saunders, E. Sodergren, P. Davis, A. Kerhornou, X. Nie, N. Hall, C. Anjard, L. Hemphill, N. Bason, P. Farbrother, B. Desany, E. Just, T. Morio, R. Rost, C. Churcher, J. Cooper, S. Haydock, N. van Driessche, A. Cronin, I. Goodhead, D. Muzny, T. Mourier, A. Pain, M. Lu, D. Harper, R. Lindsay, H. Hauser, K. James, M. Quiles, M. Madan Babu, T. Saito, C. Buchrieser, A. Wardroper, M. Felder, M. Thangavelu, D. Johnson, A. Knights, H. Loulseged, K. Mungall, K. Oliver, C. Price, M. A. Quail, H. Urushihara, J. Hernandez, E. Rabbinowitsch, D. Steffen, M. Sanders, J. Ma, Y. Kohara, S. Sharp, M. Simmonds, S. Spiegler, A. Tivey, S. Sugano, B. White, D. Walker, J. Woodward, T. Winckler, Y. Tanaka, G. Shaulsky, M. Schleicher, G. Weinstock, A. Rosenthal, E. C. Cox, R. L. Chisholm, R. Gibbs, W. F. Loomis, M. Platzer, R. R. Kay, J. Williams, P. H. Dear, A. A. Noegel, B. Barrell and A. Kuspa
doi: 10.1038/nature03481
Abstract | Full Text | PDF (968K) | Supplementary information
See also: Editor's summary
Lipoprotein particles are required for Hedgehog and Wingless signalling p58
Daniela Panáková, Hein Sprong, Eric Marois, Christoph Thiele and Suzanne Eaton
doi: 10.1038/nature03504
Abstract | Full Text | PDF (629K) | Supplementary information
See also: News and Views by Mann & Culi
Letters to Nature
Compositional maps of Saturn's moon Phoebe from imaging spectroscopy p66
Roger N. Clark, Robert H. Brown, Ralf Jaumann, Dale P. Cruikshank, Robert M. Nelson, Bonnie J. Buratti, Thomas B. McCord, J. Lunine, K. H. Baines, G. Bellucci, J.-P. Bibring, F. Capaccioni, P. Cerroni, A. Coradini, V. Formisano, Y. Langevin, D. L. Matson, V. Mennella, P. D. Nicholson, B. Sicardy, C. Sotin, Todd M. Hoefen, John M. Curchin, Gary Hansen, Karl Hibbits and K.-D. Matz
doi: 10.1038/nature03558
First paragraph | Full Text | PDF (356K)
See also: Editor's summary | News and Views by Dalton
Saturn's moon Phoebe as a captured body from the outer Solar System p69
Torrence V. Johnson and Jonathan I. Lunine
doi: 10.1038/nature03384
First paragraph | Full Text | PDF (153K)
See also: Editor's summary | News and Views by Dalton
Manipulating spin and charge in magnetic semiconductors using superconducting vortices p71
Mona Berciu, Tatiana G. Rappoport and Boldizsár Jankó
doi: 10.1038/nature03559
First paragraph | Full Text | PDF (299K) | Supplementary information
Topological versus chemical ordering in network glasses at intermediate and extended length scales p75
Philip S. Salmon, Richard A. Martin, Philip E. Mason and Gabriel J. Cuello
doi: 10.1038/nature03475
First paragraph | Full Text | PDF (296K) | Supplementary information
See also: News and Views by Madden
Measurement of femtometre-scale atomic displacements by X-ray absorption spectroscopy p78
Robert F. Pettifer, Olivier Mathon, Sakura Pascarelli, Michael D. Cooke and Michael R. J. Gibbs
doi: 10.1038/nature03516
First paragraph | Full Text | PDF (198K) | Supplementary information
See also: Editor's summary
Slip rate variations on normal faults during glacial−interglacial changes in surface loads p81
Ralf Hetzel and Andrea Hampel
doi: 10.1038/nature03562
First paragraph | Full Text | PDF (269K)
A primitive therizinosauroid dinosaur from the Early Cretaceous of Utah p84
James I. Kirkland, Lindsay E. Zanno, Scott D. Sampson, James M. Clark and Donald D. DeBlieux
doi: 10.1038/nature03468
First paragraph | Full Text | PDF (280K) | Supplementary information
See also: Editor's summary
Discovery of the first Asian plethodontid salamander p87
M. S. Min, S. Y. Yang, R. M. Bonett, D. R. Vieites, R. A. Brandon and D. B. Wake
doi: 10.1038/nature03474
First paragraph | Full Text | PDF (233K) | Supplementary information
See also: Editor's summary
An extant cichlid fish radiation emerged in an extinct Pleistocene lake p90
Domino A. Joyce, David H. Lunt, Roger Bills, George F. Turner, Cyprian Katongo, Nina Duftner, Christian Sturmbauer and Ole Seehausen
doi: 10.1038/nature03489
First paragraph | Full Text | PDF (387K) | Supplementary information
See also: Editor's summary | News and Views by Kocher
Epistasis and balanced polymorphism influencing complex trait variation p95
Juergen Kroymann and Thomas Mitchell-Olds
doi: 10.1038/nature03480
First paragraph | Full Text | PDF (241K) | Supplementary information
Suppression of Notch signalling by the COUP-TFII transcription factor regulates vein identity p98
Li-Ru You, Fu-Jung Lin, Christopher T. Lee, Francesco J. DeMayo, Ming-Jer Tsai and Sophia Y. Tsai
doi: 10.1038/nature03511
First paragraph | Full Text | PDF (609K) | Supplementary information
See also: Editor's summary
LPA3-mediated lysophosphatidic acid signalling in embryo implantation and spacing p104
Xiaoqin Ye, Kotaro Hama, James J. A. Contos, Brigitte Anliker, Asuka Inoue, Michael K. Skinner, Hiroshi Suzuki, Tomokazu Amano, Grace Kennedy, Hiroyuki Arai, Junken Aoki and Jerold Chun
doi: 10.1038/nature03505
First paragraph | Full Text | PDF (358K) | Supplementary information
See also: Editor's summary | News and Views by Dey
Cellular APOBEC3G restricts HIV-1 infection in resting CD4+ T cells p108
Ya-Lin Chiu, Vanessa B. Soros, Jason F. Kreisberg, Kim Stopak, Wes Yonemoto and Warner C. Greene
doi: 10.1038/nature03493
First paragraph | Full Text | PDF (654K) | Supplementary information
See also: Editor's summary
The bipolar mitotic kinesin Eg5 moves on both microtubules that it crosslinks p114
Lukas C. Kapitein, Erwin J. G. Peterman, Benjamin H. Kwok, Jeffrey H. Kim, Tarun M. Kapoor and Christoph F. Schmidt
doi: 10.1038/nature03503
First paragraph | Full Text | PDF (593K) | Supplementary information
A synthetic gene−metabolic oscillator p118
Eileen Fung, Wilson W. Wong, Jason K. Suen, Thomas Bulter, Sun-gu Lee and James C. Liao
doi: 10.1038/nature03508
First paragraph | Full Text | PDF (1,434K) | Supplementary information
Naturejobs
ProspectsManagement potential p123
Paul Smaglik
doi: 10.1038/nj7038-123a
Special Report
Making it in the biotech business p124
Being good at research isn't enough for success in the biotech business. Virgina Gewin finds out where to get the other skills you need.
Virginia Gewin
doi: 10.1038/nj7038-124a
Career View
Graduate Journal: Finding the balance p126
Tobias Langenhan
doi: 10.1038/nj7038-126a
Nuts & Bolts p126
Deb Koen
doi: 10.1038/nj7038-126b
Movers p126
doi: 10.1038/nj7038-126c
