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Review
Nature 434, 843-850 (14 April 2005) | doi:10.1038/nature03319
Open Innovation Challenges
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Efficient Chromosome Doubling: Plant Cell Division
The Seeker is looking for an efficient chromosome doubling method in plants and in particular, metho...
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Protect Enzyme from In Planta Degradation
A proposal for stable expression of an enzyme in corn seed is desired.
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CERC in Developmental Immunology and Immunosenescence
- Dalhousie University
- Halifax, Nova Scotia
Postdoctoral Position in Cystic Fibrosis / Pulmonary Research
- Universitatsklinikum Heidelberg
- Heidelberg 69120 Germany
Wnt signalling in stem cells and cancer
Tannishtha Reya1 & Hans Clevers2
Abstract
The canonical Wnt cascade has emerged as a critical regulator of stem cells. In many tissues, activation of Wnt signalling has also been associated with cancer. This has raised the possibility that the tightly regulated self-renewal mediated by Wnt signalling in stem and progenitor cells is subverted in cancer cells to allow malignant proliferation. Insights gained from understanding how the Wnt pathway is integrally involved in both stem cell and cancer cell maintenance and growth in the intestinal, epidermal and haematopoietic systems may serve as a paradigm for understanding the dual nature of self-renewal signals.
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