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News and Views
Nature 434, 569-570 (31 March 2005) | doi:10.1038/434569a; Published online 30 March 2005
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Sr. Scientific Manager / Chief Scientific Manager - Discovery Bioanalytical Research and Biotransformation
- Syngene International
- Bangalore, Karnataka 560099 India
Postdoctoral Positions
- Johns Hopkins University
- Baltimore, Maryland, USA
Structural biology: DNA search and rescue
Sheila S. David1
Abstract
How do DNA-repair enzymes find aberrant nucleotides among the myriad of normal ones? One enzyme has been caught in the act of checking for damage, providing clues to its quality-control process.
DNA-repair enzymes amaze us with their ability to search through vast tracts of DNA to find subtle anomalies in the structure. The human repair enzyme 8-oxoguanine glycosylase (hOGG1) is particularly impressive in this regard because it efficiently removes 8-oxoguanine (oxoG), a damaged guanine (G) base containing an extra oxygen atom, and ignores undamaged bases.
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Sheila S. David is in the Department of Chemistry, University of Utah, 315 South 1400 East, Salt Lake City, Utah
84112, USA.
e-mail: Email: david@chem.utah.edu
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