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Nature 434, 569-570 (31 March 2005) | doi:10.1038/434569a; Published online 30 March 2005

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Structural biology:  DNA search and rescue

Sheila S. David1

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How do DNA-repair enzymes find aberrant nucleotides among the myriad of normal ones? One enzyme has been caught in the act of checking for damage, providing clues to its quality-control process.

DNA-repair enzymes amaze us with their ability to search through vast tracts of DNA to find subtle anomalies in the structure. The human repair enzyme 8-oxoguanine glycosylase (hOGG1) is particularly impressive in this regard because it efficiently removes 8-oxoguanine (oxoG), a damaged guanine (G) base containing an extra oxygen atom, and ignores undamaged bases.

  1. Sheila S. David is in the Department of Chemistry, University of Utah, 315 South 1400 East, Salt Lake City, Utah 84112, USA.
    e-mail: Email: david@chem.utah.edu

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