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Nature 434, 447-448 (24 March 2005) | doi:10.1038/434447a; Published online 23 March 2005
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Physiology: Do neural signals remodel bone?
Joel K. Elmquist1 & Gordon J. Strewler1
Abstract
The hormone leptin is best known for its influence on body weight. But it also controls bone mass, and recent work in mice is beginning to uncover the neuroendocrine systems involved.
The hypothalamus is the part of the brain that maintains homeostasis, which includes regulating the autonomic nervous system — the unconscious system for monitoring and controlling the state of the body's internal organs. A key input to the hypothalamus is leptin, a hormone that is produced in fat cells to signal energy sufficiency and which affects food intake, body weight and the neuroendocrine systems1, 2, 3, 4.
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Joel K. Elmquist and Gordon J. Strewler are at the Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, Massachusetts
02215, USA.
e-mail: Email: jelmquis@bidmc.harvard.edu
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