The hormone leptin is best known for its influence on body weight. But it also controls bone mass, and recent work in mice is beginning to uncover the neuroendocrine systems involved.
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References
Ahima, R. S., Saper, C. B., Flier, J. S. & Elmquist, J. K. Front. Neuroendocrinol. 21, 263–307 (2000).
Friedman, J. M. Nutr. Rev. 60, S1–S14 (2002).
Flier, J. S. Cell 116, 337–350 (2004).
Zigman, J. M. & Elmquist, J. K. Endocrinology 144, 3749–3756 (2003).
Takeda, S. et al. Cell 111, 305–317 (2002).
Ducy, P. et al. Cell 100, 197–207 (2000).
Elefteriou, F. et al. Nature 434, 514–520 (2005).
Burt-Pichat, B. et al. Endocrinology 146, 503–510 (2005).
Pasco, J. A. et al. J. Bone Miner. Res. 19, 19–24 (2004).
Rejnmark, L. et al. Calcif. Tissue Int. 75, 365–372 (2004).
Schlienger, R. G., Kraenzlin, M. E., Jick, S. S. & Meier, C. R. J. Am. Med. Assoc. 292, 1326–1332 (2004).
Kristensen, P. et al. Nature 393, 72–76 (1998).
Elias, C. F. et al. Neuron 21, 1375–1385 (1998).
Balthasar, N. et al. Neuron 42, 983–991 (2004).
Elias, C. F. et al. J. Comp. Neurol. 432, 1–19 (2001).
Reseland, J. E. & Gordeladze, J. O. FEBS Lett. 528, 40–42 (2002).
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Elmquist, J., Strewler, G. Do neural signals remodel bone?. Nature 434, 447–448 (2005). https://doi.org/10.1038/434447a
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DOI: https://doi.org/10.1038/434447a
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