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Nature 433, 467-468 (3 February 2005) | doi:10.1038/433467a; Published online 2 February 2005

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Cell biology:  Holding sisters for repair

Tatsuya Hirano1

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When a DNA molecule breaks, its complementary copy can be used as a template for repair. A familiar protein complex is recruited to the damaged site, keeping it close to the undamaged copy.

Before a cell divides, it must replicate its DNA, producing two identical copies of each chromosome, known as sister chromatids. When one of the sister chromatids suffers a break that affects both of its DNA strands, it is mended by 'homologous recombination'.

  1. Tatsuya Hirano is at the Cold Spring Harbor Laboratory, One Bungtown Road, Cold Spring Harbor, New York 11724, USA.
    e-mail: Email: hirano@cshl.edu

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Nature Cell Biology News and Views (01 Jul 2005)