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News and Views
Nature 433, 113-114 (13 January 2005) | doi:10.1038/433113a; Published online 12 January 2005
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Medicine: Knockout malaria vaccine?
Robert Ménard1
Abstract
An effective vaccine against malaria remains elusive. But the finding that a genetically manipulated malaria parasite can protect its host lends fresh appeal to the idea of vaccines involving live attenuated parasites.
Over the years, numerous attempts have been made to develop a vaccine against malaria, but the task is not easy. So far, one of the best prospects has been to use irradiated sporozoites — the form in which the malaria parasite is injected by the mosquito — which have proved highly protective.
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Robert Ménard is at the Institut Pasteur, 25 rue du Docteur Roux, Paris
75724, France.
e-mail: Email: rmenard@pasteur.fr
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