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Nature 432, 855-861 (16 December 2004) | doi:10.1038/nature03193; Published online 15 December 2004
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review article Navigating chemical space for biology and medicine
Christopher Lipinski1 & Andrew Hopkins2
Abstract
Despite over a century of applying organic synthesis to the search for drugs, we are still far from even a cursory examination of the vast number of possible small molecules that could be created. Indeed, a thorough examination of all 'chemical space' is practically impossible. Given this, what are the best strategies for identifying small molecules that modulate biological targets? And how might such strategies differ, depending on whether the primary goal is to understand biological systems or to develop potential drugs?
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