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Brief Communications
Nature 432, 822 (16 December 2004) | doi:10.1038/432822a; Published online 15 December 2004
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Neurosurgery: Functional regeneration after laser axotomy
Mehmet Fatih Yanik1, Hulusi Cinar2, Hediye Nese Cinar2, Andrew D. Chisholm2, Yishi Jin2,3 & Adela Ben-Yakar1,4
Abstract
Understanding how nerves regenerate is an important step towards developing treatments for human neurological disease1, but investigation has so far been limited to complex organisms (mouse and zebrafish2) in the absence of precision techniques for severing axons (axotomy). Here we use femtosecond laser surgery for axotomy in the roundworm Caenorhabditis elegans and show that these axons functionally regenerate after the operation. Application of this precise surgical technique should enable nerve regeneration to be studied in vivo in its most evolutionarily simple form.
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