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Nature 432, 338-341 (18 November 2004) | doi:10.1038/nature03099; Published online 17 November 2004
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Direct Molecular Detection of Proteins and Nucleic Acids
This Challenge is looking for novel approaches to protein and nucleic acid detection. This is an Id...
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Methods of Modeling Adaptation in Populations
The analysis of adaptation with a population is a frequently encountered computational modeling scen...
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Molecular Biologist (Positions Open in Bacteria, Fungal and Yeast Streams)
- Praj Matrix - Praj Industries Ltd
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- The Scripps Research Institute
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Progress Aneuploidy and cancer
Harith Rajagopalan1 & Christoph Lengauer1
Abstract
In contrast to normal cells, aneuploidy — alterations in the number of chromosomes — is consistently observed in virtually all cancers. A growing body of evidence suggests that aneuploidy is often caused by a particular type of genetic instability, called chromosomal instability, which may reflect defects in mitotic segregation in cancer cells. A better understanding of the molecular mechanisms leading to aneuploidy holds promise for the development of cancer drugs that target this process.
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