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Nature 432, 286-287 (18 November 2004) | doi:10.1038/432286a; Published online 17 November 2004
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Gastroenterologist
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- La Crosse, Wisconsin, USA
Neuropathology Assistant or Associate Research Professor
- Indiana University School of Medicine
- Indiana, USA
Structural biology: Ion pump in the movies
C. Roy D. Lancaster1
Abstract
Insight into how membrane ion pumps work requires structural snapshots of various stages of their catalytic cycle. Now a fifth freeze-frame image of a calcium pump in action adds to a striking body of work on this protein.
On page 361 of this issue, Toyoshima and colleagues1 reveal the latest in a series of high-resolution, three-dimensional snapshots of an ion pump at work. The pump in question is powered by adenosine triphosphate (ATP) molecules and moves calcium ions across biological membranes — an activity that is crucial for skeletal muscle to function.
- C. Roy D. Lancaster is in the Department of Molecular Membrane Biology, Max Planck Institute of Biophysics, Marie-Curie-Strasse 15, D-60439 Frankfurt am Main, Germany.
e-mail: Email: roy.lancaster@mpibp-frankfurt.mpg.de
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