Table of contents
Volume 431 Number 7007 pp385-489
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Editorials
No farewell to arms? p385
If North Korea is to bid farewell to nuclear arms, negotiators will have to convince the country that its neighbours do not themselves want to become nuclear powers. Recent activities in Japan and South Korea will make this harder.
doi:10.1038/431385a
Time to look to the future p385
Germany is understandably cautious about embryo research, but the country would benefit from joint European projects.
doi:10.1038/431385b
News
European space scientists brim with ideas for going it alone p387
Space meeting urges ESA to follow its own path.
Quirin Schiermeier
doi:10.1038/431387a
Bush backs Bement to head science agency p388
Next director nominated for US National Science Foundation.
Geoff Brumfiel
doi:10.1038/431388a
Hurricane Ivan highlights future risk for New Orleans p388
Wetland restoration could prevent disastrous flooding.
Tony Reichhardt
doi:10.1038/431388b
Surgeons seek go-ahead to perform first face transplant p389
Proposal says benefits eclipse ethical concerns.
Erika Check
doi:10.1038/431389a
US health agency opens landmark clinical centre p389
Special labs promised for obesity research.
Helen Pearson
doi:10.1038/431389b
Students set up forum to debate hot topics p390
Seattle meetings get scientists and public chatting.
Jonathan Knight
doi:10.1038/431390a
Research plane will scale uncharted heights p390
German aircraft set to study the skies.
Quirin Schiermeier
doi:10.1038/431390b
Study warns of 'avoidable' risks of CT scans p391
Reduce X-ray doses for children, urge researchers.
Jim Giles
doi:10.1038/431391a
Digital mastery peers through cracks at early Picasso p391
Lab analysis reveals hidden painting.
Barbara Simm
doi:10.1038/431391b
News Features
Oceanography: Deckchair science p394
There are worse places to do research, but for the Caribbean cruise ship Explorer of the Seas, home to two climate laboratories, it's not all smooth sailing. Emma Marris finds out why.
doi:10.1038/431394a
Enzymes: By chance, or by design? p396
Enzymes are well known for speeding up reactions. But have they evolved to use quantum mechanics to exert their effects? Philip Ball meets the researchers who are trying to find out.
doi:10.1038/431396a
Correspondence
School arrays benefit science as well as students p398
While cosmic rays arouse interest in physics, more rare phenomena may be spotted.
James L. Pinfold
doi:10.1038/431398a
Hopes remain for an Alzheimer's vaccine p398
Dale Schenk
doi:10.1038/431398b
German reforms would make little difference p398
Thomas Carell
doi:10.1038/431398c
Books and Arts
A duet on speciation p399
A synthesis of ideas about how species arise hits the right note.
Axel Meyer reviews Speciation by Jerry A. Coyne and H. Allen Orr
doi:10.1038/431399a
Something to chew on p400
Daniel E. Lieberman reviews Dental Functional Morphology: How Teeth Work by Peter W. Lucas
doi:10.1038/431400a
The geography of life p401
Mark Williamson reviews Foundations of Biogeography: Classic Papers with Commentaries
doi:10.1038/431401a
Science in culture p401
Zeger Reyers saturates the senses with his installation Aqua Boogie.
Colin Martin
doi:10.1038/431401b
Essay
ConceptMending and malignancy p402
Carcinogenesis and tissue repair: how might chronic tissue injury lead to the development of cancer?
Philip A. Beachy, Sunil S. Karhadkar and David M. Berman
doi:10.1038/431402a
News and Views
Ecology: Ethics and amphibians p403
A statistical study shows convincingly that a technique for marking frogs in ecological field experiments compromises the results. Present practices need a rethink — and not only for practical reasons.
Robert M. May
doi:10.1038/431403a
Molecular physics: Break-up breakdown p404
Molecules ionize and fragment when subjected to energetic radiation. The behaviour of a simple molecule, deuterium, can now be tracked through this process in greater detail than ever before.
Tim Reddish
doi:10.1038/431404a
Cancer: An inflammatory link p405
The NF-
B protein is a key player in inflammation. It now seems that it might also activate signalling pathways, in both cancer cells and tumour-associated inflammatory cells, that promote malignancy.
Fran Balkwill and Lisa M. Coussens
doi:10.1038/431405a
Global change: Carbon conundrum on the tundra p406
Vast amounts of carbon are locked into soils at northern high latitudes. The vexed question of how these ecosystems will respond to global warming is addressed by a long-term experiment in the Arctic.
Wendy M. Loya and Paul Grogan
doi:10.1038/431406a
Evolution: A is for adaptation p408
Studies of a bacterial virus have revealed an unexpected weapon that helps it to overcome its host's rapidly changing defences. A look at other organisms hints that the mechanism might be widespread.
Jef D. Boeke
doi:10.1038/431408a
Biological techniques: Tailor-made riboswitches p409
Angela K. Eggleston
doi:10.1038/431409a
100 and 50 years ago p410
doi:10.1038/431410a
Materials science: The art of restoration p410
There are various techniques for the restoration of artwork — how effective and safe these are also varies. 'Reversible' gels could, however, provide a less risky way to reverse the ravages of time.
David Erhardt
doi:10.1038/431410b
Environmental geography: Treeless at Easter p411
Henry Gee
doi:10.1038/431411a
Brief Communications
Analgesia: Morphine-pathway block in top1 poppies p413
This opium poppy mutant provides chemical precursors for non-addictive analgesics.
Anthony G. Millgate, Barry J. Pogson, Iain W. Wilson, Toni M. Kutchan, Meinhart H. Zenk, Wayne L. Gerlach, Anthony J. Fist and Philip J. Larkin
doi:10.1038/431413a
First paragraph | Full Text | PDF (354K) | Supplementary information
Ecology: Widespread colonization by polar hypoliths p414
Charles S. Cockell and M. Dale Stokes
doi:10.1038/431414a
First paragraph | Full Text | PDF (214K) | Supplementary information
Top of page
Brief Communications Arising
Corrigendum: Physiology: Does gut hormone PYY3–36 decrease food intake in rodents?
doi:10.1038/nature03019
Article
Impaired PtdIns(4,5)P2 synthesis in nerve terminals produces defects in synaptic vesicle trafficking p415
Gilbert Di Paolo, Howard S. Moskowitz, Keith Gipson, Markus R. Wenk, Sergey Voronov, Masanori Obayashi, Richard Flavell, Reiko M. Fitzsimonds, Timothy A. Ryan and Pietro De Camilli
doi:10.1038/nature02896
Abstract | Full Text | PDF (474K) | Supplementary information
Letters to Nature
Inhibition of carbonate synthesis in acidic oceans on early Mars p423
Alberto G. Fairén, David Fernández-Remolar, James M. Dohm, Victor R. Baker and Ricardo Amils
doi:10.1038/nature02911
First paragraph | Full Text | PDF (247K)
A high-intensity highly coherent soft X-ray femtosecond laser seeded by a high harmonic beam p426
Ph. Zeitoun, G. Faivre, S. Sebban, T. Mocek, A. Hallou, M. Fajardo, D. Aubert, Ph. Balcou, F. Burgy, D. Douillet, S. Kazamias, G. de Lachèze-Murel, T. Lefrou, S. le Pape, P. Mercère, H. Merdji, A. S. Morlens, J. P. Rousseau and C. Valentin
doi:10.1038/nature02883
First paragraph | Full Text | PDF (296K) | Supplementary information
Demonstration of a quantum teleportation network for continuous variables p430
Hidehiro Yonezawa, Takao Aoki and Akira Furusawa
doi:10.1038/nature02858
First paragraph | Full Text | PDF (296K)
A Taylor vortex analogy in granular flows p433
Stephen L. Conway, Troy Shinbrot and Benjamin J. Glasser
doi:10.1038/nature02901
First paragraph | Full Text | PDF (318K)
Complete photo-fragmentation of the deuterium molecule p437
T. Weber, A. O. Czasch, O. Jagutzki, A. K. Müller, V. Mergel, A. Kheifets, E. Rotenberg, G. Meigs, M. H. Prior, S. Daveau, A. Landers, C. L. Cocke, T. Osipov, R. Díez Muiño, H. Schmidt-Böcking and R. Dörner
doi:10.1038/nature02839
First paragraph | Full Text | PDF (408K)
See also: News and Views by Reddish
Ecosystem carbon storage in arctic tundra reduced by long-term nutrient fertilization p440
Michelle C. Mack, Edward A. G. Schuur, M. Syndonia Bret-Harte, Gaius R. Shaver and F. Stuart Chapin, III
doi:10.1038/nature02887
First paragraph | Full Text | PDF (182K) | Supplementary information
See also: News and Views by Loya & Grogan
Environmental predictors of pre-European deforestation on Pacific islands p443
Barry Rolett and Jared Diamond
doi:10.1038/nature02801
First paragraph | Full Text | PDF (126K) | Supplementary information
Male mammals respond to a risk of sperm competition conveyed by odours of conspecific males p446
Javier delBarco-Trillo and Michael H. Ferkin
doi:10.1038/nature02845
First paragraph | Full Text | PDF (207K)
Theory predicts the uneven distribution of genetic diversity within species p449
Erik M. Rauch and Yaneer Bar-Yam
doi:10.1038/nature02745
First paragraph | Full Text | PDF (274K) | Supplementary information
A frequency-dependent switch from inhibition to excitation in a hippocampal unitary circuit p453
Masahiro Mori, Mathias H. Abegg, Beat H. Gähwiler and Urs Gerber
doi:10.1038/nature02854
First paragraph | Full Text | PDF (271K) | Supplementary information
Regulation of B-cell survival by BAFF-dependent PKC
-mediated nuclear signalling p456
Ingrid Mecklenbräuker, Susan L. Kalled, Michael Leitges, Fabienne Mackay and Alexander Tarakhovsky
doi:10.1038/nature02955
First paragraph | Full Text | PDF (630K) | Supplementary information
NF-
B functions as a tumour promoter in inflammation-associated cancer p461
Eli Pikarsky, Rinnat M. Porat, Ilan Stein, Rinat Abramovitch, Sharon Amit, Shafika Kasem, Elena Gutkovich-Pyest, Simcha Urieli-Shoval, Eithan Galun and Yinon Ben-Neriah
doi:10.1038/nature02924
First paragraph | Full Text | PDF (1,029K) | Supplementary information
See also: News and Views by Balkwill & Coussens
Mrf4 determines skeletal muscle identity in Myf5:Myod double-mutant mice p466
Lina Kassar-Duchossoy, Barbara Gayraud-Morel, Danielle Gomès, Didier Rocancourt, Margaret Buckingham, Vasily Shinin and Shahragim Tajbakhsh
doi:10.1038/nature02876
First paragraph | Full Text | PDF (2,263K) | Supplementary information
Exogenous control of mammalian gene expression through modulation of RNA self-cleavage p471
Laising Yen, Jennifer Svendsen, Jeng-Shin Lee, John T. Gray, Maxime Magnier, Takashi Baba, Robert J. D'Amato and Richard C. Mulligan
doi:10.1038/nature02844
First paragraph | Full Text | PDF (456K) | Supplementary information
Tropism switching in Bordetella bacteriophage defines a family of diversity-generating retroelements p476
Sergei Doulatov, Asher Hodes, Lixin Dai, Neeraj Mandhana, Minghsun Liu, Rajendar Deora, Robert W. Simons, Steven Zimmerly and Jeff F. Miller
doi:10.1038/nature02833
First paragraph | Full Text | PDF (771K) | Supplementary information
See also: News and Views by Boeke
High-resolution structure of a retroviral capsid hexameric amino-terminal domain p481
Gulnahar B. Mortuza, Lesley F. Haire, Anthony Stevens, Stephen J. Smerdon, Jonathan P. Stoye and Ian A. Taylor
doi:10.1038/nature02915
First paragraph | Full Text | PDF (384K)
Corrigendum: Absence of S6K1 protects against age- and diet-induced obesity while enhancing insulin sensitivity p485
Sung Hee Um, Francesca Frigerio, Mitsuhiro Watanabe, Frédéric Picard, Manel Joaquin, Melanie Sticker, Stefano Fumagalli, Peter R. Allegrini, Sara C. Kozma, Johan Auwerx and George Thomas
doi:10.1038/nature02979
Naturejobs
ProspectsThe uncertainty principle p487
Paul Smaglik
doi:10.1038/nj7007-487a
Postdocs
Spain aims at preimier league p488
Could Spain kick off its legacy of inertia and win as much fame for research as for football? It's backing some of its star players with schemes to promote fresh talent, says Quirin Schiermeier.
Quirin Schiermeier
doi:10.1038/nj7007-488a