Access
To read this story in full you will need to login or make a payment (see right).
News and Views
Nature 429, 708-709 (17 June 2004) | doi:10.1038/429708a
Open Innovation Challenges
-
Single-cell Analysis Platform
This Challenge is looking for novel approaches to analyzing changes at a single-cell level. This is...
-
Novel Approaches to Protecting Maize from Insect Damage
The Seeker is looking for novel approaches to protecting maize from insect damage. This Challenge re...
- More Challenges
- Powered by:
nature jobs
Natural Products Chemist
- Praj Matrix - Praj Industries Ltd
- Pune, Maharashtra Pune-411021 India
Instrumentation Engineer
- Praj Matrix - Praj Industries Ltd
- Pune, Maharashtra Pune-411021 India
Molecular biology: The loader of the rings
Michael A. Trakselis1 & Stephen D. Bell1
Abstract
Among the numerous molecular machines involved in the process of DNA replication are the ring-shaped sliding clamp and the clamp loader. Intriguing structural details of their interaction are now revealed.
The double-helical structure of DNA is an icon of our time, appearing almost daily as a backdrop to news stories about medical advances and in myriad sci-fi movies. The molecule itself consists of two inter-wound strands, the backbones of which are composed of alternating phosphate and sugar groups.
- Michael A. Trakselis and Stephen D. Bell are in the Medical Research Council Cancer Cell Unit, Hutchison MRC Research Centre, Hills Road, Cambridge CB2 2XZ, UK.
e-mails: Email: sb419@cam.ac.uk
Email: mt339@cam.ac.uk
To read this story in full you will need to login or make a payment (see right).
MORE ARTICLES LIKE THIS
These links to content published by NPG are automatically generated.
NEWS AND VIEWS
'Screw-cap' clamp loader proteins that threadNature Structural & Molecular Biology News and Views (01 Jul 2004)
A sliding clamp monkey wrenchNature Structural Biology News and Views (01 Oct 2001)
RESEARCH
The clamp-loading complex for processive DNA replicationNature Structural & Molecular Biology Article (01 Jul 2004)
Communication between subunits within an archaeal clamp-loader complexThe EMBO Journal Article (17 May 2006)
See all 15 matches for Research