Insulin-producing β-cells in the adult pancreas were thought to derive from pancreatic stem cells. But it seems that they arise abundantly from β-cells themselves, offering a new outlook on regenerative medicine.
This is a preview of subscription content, access via your institution
Access options
Subscribe to this journal
Receive 51 print issues and online access
$199.00 per year
only $3.90 per issue
Buy this article
- Purchase on Springer Link
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
References
Shapiro, A. M. N. Engl. J. Med. 343, 230–238 (2000).
Dor, Y., Brown, J., Martinez, O. I. & Melton, D. A. Nature 429, 41–46 (2004).
Butler, A. E. et al. Diabetes 52, 102–110 (2003).
Bonner-Weir, S., Baxter, L. A., Schuppin, G. T. & Smith, F. E. Diabetes 42, 1715–1720 (1993).
Herrera, P. L. Development 127, 2317–2322 (2000).
Rhim, J. A., Sandgren, E. P., Degen, J. L., Palmiter, R. D. & Brinster, R. L. Science 263, 1149–1152 (1994).
Overturf, K., al-Dhalimy, M., Ou, C. N., Finegold, M. & Grompe, M. Am. J. Pathol. 151, 1273–1280 (1997).
Wang, R. N., Kloppel, G. & Bouwens, L. Diabetologia 38, 1405–1411 (1995).
Tyrberg, B., Ustinov, J., Otonkoski, T. & Andersson, A. Diabetes 50, 301–307 (2001).
Lammert, E., Cleaver, O. & Melton, D. Science 294, 564–567 (2001).
Yoshitomi, H. & Zaret, K. S. Development 131, 807–817 (2004).
Thomson, J. A. et al. Science 282, 1145–1147 (1998).
Chamberlain, J. R. et al. Science 303, 1198–1201 (2004).
Hwang, W. S. et al. Science 303, 1669–1674 (2004).
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Zaret, K. Self-help for insulin cells. Nature 429, 30–31 (2004). https://doi.org/10.1038/429030a
Issue Date:
DOI: https://doi.org/10.1038/429030a
This article is cited by
-
Tracing your roots
Nature Reviews Molecular Cell Biology (2004)