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Nature 428, 813-815 (22 April 2004) | doi:10.1038/428813a
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Head of Formulation R&D
- Syngene International Limited
- Bangalore 560 099 India
Head-Preclinical
- Syngene International
- Bangalore, Karnataka 560099 India
Cancer: Enzymes play molecular tag
Deborah K. Morrison1
Abstract
The B-RAF protein is often mutated in human cancers, contributing to their development. Although most known mutations stimulate its catalytic activity, others, surprisingly, impair it — yet still cause cancer.
Like most other cellular events, cell proliferation is tightly regulated by signals from the surrounding environment. These cues are relayed from the cell surface to the nucleus by defined signal-transduction cascades.
- Deborah K. Morrison is in the Laboratory of Protein Dynamics and Signaling, Center for Cancer Research, National Cancer Institute, Frederick, Maryland 21702-1201, USA.
e-mail: Email: dmorrison@ncifcrf.gov
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