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Nature 427, 791-793 (26 February 2004) |
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HIV: Replication trimmed back
Stephen P. Goff1
Abstract
A long-standing point of intrigue has been how certain non-human primates are resistant to HIV-1. The discovery in macaque monkeys of a protein that resides in mysterious cytoplasmic bodies holds the key.
Mammals have lived with retroviruses throughout their history. To avoid the detrimental effects of these RNA viruses, mammals have evolved a large number of genes to inhibit their replication.
- Stephen P. Goff is at the Howard Hughes Medical Institute, Department of Biochemistry and Molecular Biophysics, Columbia University College of Physicians and Surgeons, New York 10032, USA.
e-mail: Email: goff@cancercenter.columbia.edu
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