Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • News & Views
  • Published:

Turning the key on p53

Nature volume 427, pages 789–790 (2004)Cite this article

The p53 protein is among the most effective of the body's natural defences against cancer. News comes of a promising way of releasing the protein from its inhibitions to carry out its anti-tumour duties.

This is a preview of subscription content, access via your institution

Relevant articles

Open Access articles citing this article.

Access options

Buy this article

  • Purchase on Springer Link
  • Instant access to full article PDF
Buy now

Prices may be subject to local taxes which are calculated during checkout

Figure 1: Inhibiting the inhibitor.

References

  1. Lane, D. P. & Crawford, L. V. Nature 278, 261–263 (1979).

    Article  ADS  CAS  Google Scholar 

  2. Vousden, K. H. & Lu, X. Nature Rev. Cancer 2, 594–604 (2002).

    Article  CAS  Google Scholar 

  3. Surendran, A. Nature Med. 10, 9 (2004).

    Article  Google Scholar 

  4. Snyder, E. L. et al. PLoS Biol. doi: 10.1371/journal.pbio.0020036 (2004).

  5. Vassilev, L. T. et al. Science 303, 844–848 (2004).

    Article  ADS  CAS  Google Scholar 

  6. Gudkov, A. V. & Komarova, E. A. Nature Rev. Cancer 3, 117–129 (2003).

    Article  CAS  Google Scholar 

  7. Iwakuma, T. & Lozano, G. Mol. Cancer Res. 1, 993–1000 (2003).

    CAS  PubMed  Google Scholar 

  8. Montes de Oca Luna, R., Wagner, D. S. & Lozano, G. Nature 378, 203–206 (1995).

    Article  ADS  CAS  Google Scholar 

  9. Chene, P. Nature Rev. Cancer 3, 102–109 (2003).

    Article  ADS  CAS  Google Scholar 

  10. Mendrysa, S. M. et al. Mol. Cell. Biol. 23, 462–473 (2003).

    Article  CAS  Google Scholar 

  11. O'Leary, K. A. et al. Mol. Cell. Biol. 24, 186–191 (2004).

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Cancer Research UK Laboratories, Ninewells Hospital and Medical School, Dundee, DD1 9SY, UK

    David P. Lane

  2. Cyclacel Ltd,

    David P. Lane

  3. Cyclacel Ltd, James Lindsay Place, Dundee Technopole, Dundee, DD1 5JJ, UK

    Peter M. Fischer

Authors
  1. David P. Lane
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Peter M. Fischer
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

Lane, D., Fischer, P. Turning the key on p53. Nature 427, 789–790 (2004). https://doi.org/10.1038/427789a

Download citation

  • Issue Date:

  • DOI: https://doi.org/10.1038/427789a

This article is cited by

Search

Advanced search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing