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Neurobiology

A move to sort life from death

Nature volume 427, pages 798–799 (2004)Cite this article

Nerve growth factor determines neuronal cell fate during development or after injury. A newly identified ‘death factor’, an unprocessed form of this protein, induces cell death by activating two receptors in concert.

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Figure 1: Roles of p75NTR and its co-receptors — TrkA, sortilin and NogoR — in the nervous system.

References

  1. Nykjaer, A. et al. Nature 427, 843–848 (2004).

    Article  ADS  CAS  Google Scholar 

  2. Levi-Montalcini, R. Science 237, 1154–1162 (1987).

    Article  ADS  CAS  Google Scholar 

  3. Hempstead, B. L. Curr. Opin. Neurobiol. 12, 260–267 (2002).

    Article  CAS  Google Scholar 

  4. Kaplan, D. R. & Miller, F. D. Curr. Opin. Neurobiol. 10, 381–391 (2000).

    Article  CAS  Google Scholar 

  5. Lee, R. et al. Science 294, 1945–1948 (2001).

    Article  ADS  CAS  Google Scholar 

  6. Mazella, J. Cell Signal. 13, 1–6 (2001).

    Article  CAS  Google Scholar 

  7. Sarret, P. et al. J. Comp. Neurol. 461, 483–505 (2003).

    Article  CAS  Google Scholar 

  8. Kaplan, D. R. & Miller, F. D. Nature Neurosci. 6, 435–436 (2003).

    Article  CAS  Google Scholar 

  9. McKerracher, L. & Winton, M. J. Neuron 36, 345–348 (2002).

    Article  CAS  Google Scholar 

Download references

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Authors and Affiliations

  1. Cancer Research Program,

    David R. Kaplan & Freda D. Miller

  2. Developmental Biology Program, Hospital for Sick Children, and the Department of Medical Genetics and Microbiology, University of Toronto, Toronto, M5G 1X8, Ontario, Canada

    David R. Kaplan & Freda D. Miller

Authors
  1. David R. Kaplan
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  2. Freda D. Miller
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Kaplan, D., Miller, F. A move to sort life from death. Nature 427, 798–799 (2004). https://doi.org/10.1038/427798a

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