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Nature 427, 493-494 (5 February 2004) | doi:10.1038/427493a

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Medicine: K is for koagulation

J. Evan Sadler1

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Comparative genetic linkage studies in rats, mice and humans have finally identified a key component of vitamin K metabolism that is targeted by the commonest anticoagulant drugs in use today.

Vitamins have enormous medical and economic importance. For example, the discovery of vitamin K, essential for blood clotting, led to the prevention of countless deaths from bleeding and blood clots, and facilitated the control of devastating agricultural pests.

  1. Howard Hughes Medical Institute, Washington University School of Medicine, St Louis, Missouri 63110, USA.
    Email: esadler@im.wustl.edu

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