Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • News & Views
  • Published:

Molecular Motors

Turning the ATP motor

A long-standing question regarding ATP synthase — a cellular energy-generator — has been which direction it spins in when generating ATP. Some elegant experiments have revealed the answer.

This is a preview of subscription content, access via your institution

Relevant articles

Open Access articles citing this article.

Access options

Buy this article

Prices may be subject to local taxes which are calculated during checkout

Figure 1: The binding-change model for F0F1 ATP synthase.

References

  1. Itoh, H. et al. Nature 427, 465–468 (2004).

    Article  ADS  CAS  Google Scholar 

  2. Boyer, P. D., Cross, R. L. & Momsen, W. Proc. Natl Acad. Sci. USA 70, 2837–2839 (1973).

    Article  ADS  CAS  Google Scholar 

  3. Kayalar, C., Rosing, J. & Boyer, P. D. J. Biol. Chem. 252, 2486–2491 (1977).

    CAS  PubMed  Google Scholar 

  4. Boyer, P. D. & Kohlbrenner, W. E. in Energy Coupling in Photosynthesis (eds Selman, B. & Selman-Reiner, S.) 231–240 (Elsevier North-Holland, New York, 1981).

    Google Scholar 

  5. Boekema, E. J., Ubbink-Kok, T., Lolkema, J. S., Brisson, A. & Konings, W. N. Proc. Natl Acad. Sci. USA 94, 14291–14293 (1997).

    Article  ADS  CAS  Google Scholar 

  6. Wilkens, S., Zhou, J., Nakayama, R., Dunn, S. D. & Capaldi, R. A. J. Mol. Biol. 295, 387–391 (2000).

    Article  CAS  Google Scholar 

  7. Hermolin, J., Dmitriev, O. Y., Zhang, Y. & Fillingame, R. H. J. Biol. Chem. 274, 17011–17016 (1999).

    Article  CAS  Google Scholar 

  8. Abrahams, J. P., Leslie, A. G., Lutter, R. & Walker, J. E. Nature 370, 621–628 (1994).

    Article  ADS  CAS  Google Scholar 

  9. Duncan, T. M., Bulygin, V. V., Zhou, Y., Hutcheon, M. L. & Cross, R. L. Proc. Natl Acad. Sci. USA 92, 10964–10968 (1995).

    Article  ADS  CAS  Google Scholar 

  10. Sabbert, D., Engelbrecht, S. & Junge, S. Nature 381, 623–625 (1996).

    Article  ADS  CAS  Google Scholar 

  11. Noji, H., Yasuda, R., Yoshida, M. & Kinosita, K. Jr Nature 386, 299–302 (1997).

    Article  ADS  CAS  Google Scholar 

  12. Zhou, Y., Duncan, T. M. & Cross, R. L. Proc. Natl Acad. Sci. USA 94, 10583–10587 (1997).

    Article  ADS  CAS  Google Scholar 

  13. Sabbert, D. & Junge, W. Proc. Natl Acad. Sci. USA 94, 2312–2317 (1997).

    Article  ADS  CAS  Google Scholar 

  14. Adachi, K. et al. Proc. Natl Acad. Sci. USA 97, 7243–7247 (2000).

    Article  ADS  CAS  Google Scholar 

  15. Diez, M. et al. Nature Struct. Mol. Biol. 11, 135–141 (2004).

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Rights and permissions

Reprints and permissions

About this article

Cite this article

Cross, R. Turning the ATP motor. Nature 427, 407–408 (2004). https://doi.org/10.1038/427407b

Download citation

  • Issue Date:

  • DOI: https://doi.org/10.1038/427407b

This article is cited by

Search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing