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Insight
Nature 426, 891-894 (18 December 2003) | doi:10.1038/nature02262
progress Quality control in the endoplasmic reticulum protein factory
Roberto Sitia1 & Ineke Braakman2
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Abstract
The endoplasmic reticulum (ER) is a factory where secretory proteins are manufactured, and where stringent quality-control systems ensure that only correctly folded proteins are sent to their final destinations. The changing needs of the ER factory are monitored by integrated signalling pathways that constantly adjust the levels of folding assistants. ER chaperones and signalling molecules are emerging as drug targets in amyloidoses and other protein-conformational diseases.
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