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Nature 426, 238-239 (20 November 2003) | doi:10.1038/426238a

Signal transduction: An eye on organ development

Jonathan A. Epstein1 & Benjamin G. Neel2

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Studies in flies and mice have revealed a surprising way in which cells regulate gene activity, with consequences for our understanding of organ formation during development.

The processes by which cells receive outside signals and transmit them into the nucleus have been so well scrutinized that one might think few surprises remain. But three papers in this issue1, 2, 3 show otherwise.

  1. Cardiovascular Division, Department of Medicine, University of Pennsylvania, 954 BRB II, 421 Curie Boulevard, Philadelphia, Pennsylvania 19104, USA.
    Email: epsteinj@mail.med.upenn.edu
  2. Cancer Biology Program, Division of Hematology-Oncology, Department of Medicine, Beth-Israel Deaconess Medical Center, Harvard Medical School, HIM 1047, 330 Brookline Avenue, Boston, Massachusetts 02215, USA.
    Email: bneel@bidmc.harvard.edu