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Editorials

Handle with care p1

Scientists are rushing to defend a colleague charged with mishandling samples of the plague bacterium. But they must be careful not to send the message that microbiologists are blasé about the need to protect public health.

doi:10.1038/426001a


Defamation, online p1

Operators of preprint archives and other scientific websites would be well advised to get up to speed on media law.

doi:10.1038/426001b


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News

Satellite loss throws Japan's space programme into disarray p3

David Cyranoski

doi:10.1038/426003a


Disease spread leads Britain to pull plug on trial badger cull p4

Jim Giles

doi:10.1038/426004a


Florida welcomes Scripps as critics predict big-money flop p4

Rex Dalton

doi:10.1038/426004b


US loses allure in foreign students' eyes p5

Geoff Brumfiel

doi:10.1038/426005a


Roaming polar bears reveal Arctic role of pollutants p5

Marika Willerroider

doi:10.1038/426005b


Museum breaks mould in attempts to lure reluctant visitors p6

Jim Giles

doi:10.1038/426006a


National Academy calls for sea change in ocean efforts p6

Betsy Mason

doi:10.1038/426006b


Preprint server seeks way to halt plagiarists p7

Jim Giles

doi:10.1038/426007a


Critical comments threaten to open libel floodgate for physics archive p7

Jim Giles

doi:10.1038/426007b


News in brief p8

doi:10.1038/426008a


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News Features

Intellectual property: This protein belongs to... p10

The early days of genomics were marked by concerns that wide-ranging gene patents would restrict research and medical discovery. So far, proteomics hasn't toiled under the same cloud. But don't get complacent, warns David Cyranoski.

doi:10.1038/426010a


Marine biology: Close encounters of the jelly kind p12

Deep-diving submarines have opened a new window onto the ocean's gelatinous inhabitants. And biologists are discovering that these denizens of the deep have a few surprises in store. Carina Dennis dives in.

doi:10.1038/426012a


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Correspondence

Leonardo knew the fluid boundaries of science p15

Without the aid of mathematical models, his ideas stemmed from keen observation.

Stefano E. Grillo

doi:10.1038/426015a


Open access: other ways p15

Peter Suber

doi:10.1038/426015b


Open access will deter illegal file-sharing p15

Martin Dufva

doi:10.1038/426015c


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Books and Arts

The history of cool p17

A look back at pioneering studies of quantum effects at low temperatures.

Philip W. Anderson reviews Cold Wars: A History of Superconductivity by Jean Matricon and Georges Waysand

doi:10.1038/426017a


The rise and fall of populations p18

Nils Chr. Stenseth reviews Complex Population Dynamics: A Theoretical/Empirical Synthesis by Peter Turchin

doi:10.1038/426018a


Exhibition: Force of nature p19

Alison Abbott

doi:10.1038/426019a


Rambling in the rain p19

Philippe Janvier reviews The Cruise of the Betsey with Rambles of a Geologist by Hugh Miller, T. C. Smout and M. A. Taylor

doi:10.1038/426019b


More on Miller p19

doi:10.1038/426019c


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Lifelines

Terry L. Root: Following the thread p20

Terry L. Root is a senior fellow in the Center for Environmental Science and Policy at the Stanford Institute for International Studies. She is an ecologist who specializes in conservation biology, biogeography and ornithology.

doi:10.1038/426020a


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News and Views

Planetary Science: Over the edge? p21

The two Voyager spacecraft are heading beyond the bounds of the Solar System, and Voyager 1 may now have encountered the 'edge' — the termination shock — of the solar wind. But not everyone agrees.

Len A. Fisk

doi:10.1038/426021a


Evolutionary biology: Scramble for the eggs p22

Copulating cockerels can, it seems, tailor their ejaculate to several factors: the degree of male competition, whether they have mated with the female before, and the female's reproductive 'value'.

Matthew J. G. Gage

doi:10.1038/426022a


Microbiology: Destructive approach p23

Amanda Tromans

doi:10.1038/426023a


Femtophysics: Birth of a quasiparticle p23

As electronic devices shrink, the interaction between electrons and the silicon crystal lattice, described in terms of 'quasiparticles', is a central issue. Ultrashort laser pulses can track the birth of such a quasiparticle.

Alfred Leitenstorfer

doi:10.1038/426023b


Neurobiology: Signals that make waves p25

Neurons in the brain release proteins called neurotrophins, which bind to glial cells and unleash a wave of calcium ions inside them. This could be the missing link in a communication circuit between glia and neurons.

Louis F. Reichardt

doi:10.1038/426025a


100 and 50 years ago p25

doi:10.1038/426025b


Ecology: Palms in motion p26

Being eaten alive then dumped with the resulting droppings can be all to the good — if you are a palm fruit in the Amazonian tropical forest, that is, and the consumer is a large mammal.

Peter D. Moore

doi:10.1038/426026a


Cell biology: Enlightened messages p27

Clare Thomas

doi:10.1038/426027a


Editorial note p27

doi:10.1038/426027b


News and views in brief p28

doi:10.1038/426028a


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Brief Communications

Wetlands: Crop freezes and land-use change in Florida p29

Draining the state's southern wetlands may have raised the incidence of harmful frosts.

Curtis H. Marshall, Roger A. Pielke, Sr and Louis T. Steyaert

doi:10.1038/426029a


Arachnology: Scavenging by brown recluse spiders p30

Jamel S. Sandidge

doi:10.1038/426030a


Biophysics (communication arising): Is rhodopsin dimeric in native retinal rods? p30

Marc Chabre, Richard Cone and Helen Saibil

doi:10.1038/426030b


Biophysics (communication arising): Is rhodopsin dimeric in native retinal rods? p31

Dimitrios Fotiadis, Yan Liang, Slawomir Filipek, David A. Saperstein, Andreas Engel and Krzysztof Palczewski

doi:10.1038/426031a


Global carbon cycle (communication arising): Metabolic balance of the open sea p32

David M. Karl, Edward A. Laws, Paul Morris, Peter J. leB. Williams and Steven Emerson

doi:10.1038/426032a


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Review

The immune response of Drosophila p33

Jules A. Hoffmann

doi:10.1038/nature02021


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Article

Structure of mitochondrial ADP/ATP carrier in complex with carboxyatractyloside p39

Eva Pebay-Peyroula, Cécile Dahout-Gonzalez, Richard Kahn, Véronique Trézéguet, Guy J.-M. Lauquin and Gérard Brandolin

doi:10.1038/nature02056


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Letters to Nature

Voyager 1 exited the solar wind at a distance of approx85 au from the Sun p45

S. M. Krimigis, R. B. Decker, M. E. Hill, T. P. Armstrong, G. Gloeckler, D. C. Hamilton, L. J. Lanzerotti and E. C. Roelof

doi:10.1038/nature02068

See also: News and Views by Fisk


Enhancements of energetic particles near the heliospheric termination shock p48

Frank B. McDonald, Edward C. Stone, Alan C. Cummings, Bryant Heikkila, Nand Lal and William R. Webber

doi:10.1038/nature02066

See also: News and Views by Fisk


The birth of a quasiparticle in silicon observed in time–frequency space p51

Muneaki Hase, Masahiro Kitajima, Anca Monia Constantinescu and Hrvoje Petek

doi:10.1038/nature02044

See also: News and Views by Leitenstorfer


Magnetic control of ferroelectric polarization p55

T. Kimura, T. Goto, H. Shintani, K. Ishizaka, T. Arima and Y. Tokura

doi:10.1038/nature02018


Self-assembly in aqueous solution of wheel-shaped Mo154 oxide clusters into vesicles p59

Tianbo Liu, Ekkehard Diemann, Huilin Li, Andreas W. M. Dress and Achim Müller

doi:10.1038/nature02036


Interaction of sea water and lava during submarine eruptions at mid-ocean ridges p62

Michael R. Perfit, Johnson R. Cann, Daniel J. Fornari, Jennifer Engels, Deborah K. Smith, W. Ian Ridley and Margo H. Edwards

doi:10.1038/nature02032


Sulphide mining by the superextensile foot of symbiotic thyasirid bivalves p65

Suzanne C. Dufour and Horst Felbeck

doi:10.1038/nature02095


Governance and the loss of biodiversity p67

R. J. Smith, R. D. J. Muir, M. J. Walpole, A. Balmford and N. Leader-Williams

doi:10.1038/nature02025


Sophisticated sperm allocation in male fowl p70

Tommaso Pizzari, Charles K. Cornwallis, Hanne Løvlie, Sven Jakobsson and Tim R. Birkhead

doi:10.1038/nature02004

See also: News and Views by Gage


Truncated TrkB-T1 mediates neurotrophin-evoked calcium signalling in glia cells p74

Christine R. Rose, Robert Blum, Bruno Pichler, Alexandra Lepier, Karl W. Kafitz and Arthur Konnerth

doi:10.1038/nature01983

See also: News and Views by Reichardt


Methylation at lysine 4 of histone H3 in ecdysone-dependent development of Drosophila p78

Yurii Sedkov, Elizabeth Cho, Svetlana Petruk, Lucy Cherbas, Sheryl T. Smith, Richard S. Jones, Peter Cherbas, Eli Canaani, James B. Jaynes and Alexander Mazo

doi:10.1038/nature02080


Hedgehog signalling in the mouse requires intraflagellar transport proteins p83

Danwei Huangfu, Aimin Liu, Andrew S. Rakeman, Noel S. Murcia, Lee Niswander and Kathryn V. Anderson

doi:10.1038/nature02061


Degradation of Cdc25A by beta-TrCP during S phase and in response to DNA damage p87

Luca Busino, Maddalena Donzelli, Massimo Chiesa, Daniele Guardavaccaro, Dvora Ganoth, N. Valerio Dorrello, Avram Hershko, Michele Pagano and Giulio F. Draetta

doi:10.1038/nature02082


Structural adaptability in the ligand-binding pocket of the ecdysone hormone receptor p91

Isabelle M. L. Billas, Thomas Iwema, Jean-Marie Garnier, André Mitschler, Natacha Rochel and Dino Moras

doi:10.1038/nature02112


Crystal structure of a zinc-finger–RNA complex reveals two modes of molecular recognition p96

Duo Lu, M. Alexandra Searles and Aaron Klug

doi:10.1038/nature02088


Addendum: An expressed pseudogene regulates the messenger-RNA stability of its homologous coding gene p100

Shinji Hirotsune, Noriyuki Yoshida, Amy Chen, Lisa Garrett, Fumihiro Sugiyama, Satoru Takahashi, Ken-ichi Yagami, Anthony Wynshaw-Boris and Atsushi Yoshiki

doi:10.1038/nature02094


Retraction: Hes1 is a target of microRNA-23 during retinoic-acid-induced neuronal differentiation of NT2 cells p100

Hiroaki Kawasaki and Kazunari Taira

doi:10.1038/nature02141


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Naturejobs

Prospects

Trust me, I'm a doctor p101

Paul Smaglik

doi:10.1038/nj6962-101a


POSTDOCS

A winning proposal p102

Young, aspiring researchers often have to learn the hard way when it comes to writing a killer grant application. But a range of European initiatives aims to give them a helping hand. Karen Kreeger reports.

Karen Kreeger

doi:10.1038/nj6962-102a


Career View

Young Scientist: Paying the rent p104

doi:10.1038/nj6962-104a


Nuts & Bolts p104

Deb Koen

doi:10.1038/nj6962-104b


Movers p104

doi:10.1038/nj6962-104c


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