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Nature 426, 23 (6 November 2003) | doi:10.1038/426023a

Open Innovation Challenges

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Microbiology: Destructive approach

Amanda Tromans

In the latest example of the wiliness of infectious bacteria, Tomoko Kubori and Jorge E. Galán have shown that Salmonella typhimurium exploits its host's protein-degradation machinery in order to reverse the substantial cellular reorganization that allows the bacterium to gain entry (Cell 115, 333–342; 2003).