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Nature 425, 778-779 (23 October 2003) | doi:10.1038/425778a
Stem cells: Interactive niches
Ihor R. Lemischka1 & Kateri A. Moore1
Abstract
The microenvironment, or niche, in which stem cells reside controls their renewal and maturation. The niche that regulates blood-forming stem cells in adult animals has eluded researchers — until now.
Cell-fate decisions in the developing embryo are governed by a complex interplay between cell-autonomous signals and stimuli from the surrounding tissue — the microenvironment. Similar processes control the birth and maturation of stem cells that replenish mature cell populations in adults1, 2.
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