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Neurobiology

Double trouble for neurons

Nature volume 425, pages 565–566 (2003)Cite this article

Mutations in the presenilin protein are associated with Alzheimer's disease. It now seems that mutant presenilin could wreak havoc on neuronal functions by triggering the activation of certain genes.

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Figure 1: Two functions of presenilin.

References

  1. O'Brien, C. Science 273, 28 (1996).

    Article  ADS  CAS  Google Scholar 

  2. Marambaud, P. et al. Cell 114, 635–645 (2003).

    Article  CAS  Google Scholar 

  3. Selkoe, D. J. Trends Cell Biol. 8, 447–453 (1998).

    Article  CAS  Google Scholar 

  4. Sisodia, S. S. & St George-Hyslop, P. H. Nature Rev. Neurosci. 3, 281–290 (2002).

    Article  CAS  Google Scholar 

  5. Wolfe, M. S. & Haass, C. J. Biol. Chem. 276, 5413–5416 (2001).

    Article  CAS  Google Scholar 

  6. Marambaud, P. et al. EMBO J. 21, 1948–1956 (2002).

    Article  CAS  Google Scholar 

  7. Baki, L. et al. Proc. Natl Acad. Sci. USA 98, 2381–2386 (2001).

    Article  ADS  CAS  Google Scholar 

  8. Goodman, R. H. & Smolik, S. Genes Dev. 14, 1553–1577 (2000).

    CAS  PubMed  Google Scholar 

  9. Kandel, E. R. Science 294, 1030–1038 (2001).

    Article  ADS  CAS  Google Scholar 

  10. Amtul, Z. et al. Neurobiol. Dis. 9, 269–273 (2002).

    Article  CAS  Google Scholar 

  11. Freiman, R. N. & Tjian, R. Science 296, 2149–2150 (2002).

    Article  Google Scholar 

Download references

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  1. Laboratory of Protein Dynamics and Signalling, National Cancer Institute, 1050 Boyles Street, Frederick, 21702, Maryland, USA

    Mark E. Fortini

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  1. Mark E. Fortini
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Fortini, M. Double trouble for neurons. Nature 425, 565–566 (2003). https://doi.org/10.1038/425565a

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