Alerting the immune system to invading microorganisms is essential for effective immunity. Uric acid released by damaged cells is a danger signal that is able to notify immune cells of microbial attack.
This is a preview of subscription content, access via your institution
Relevant articles
Open Access articles citing this article.
-
Purinergic mechanism in the immune system: A signal of danger for dendritic cells
Purinergic Signalling Open Access 29 July 2005
Access options
Subscribe to this journal
Receive 51 print issues and online access
$199.00 per year
only $3.90 per issue
Buy this article
- Purchase on Springer Link
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
References
Shi, Y., Evans, J. E. & Rock, K. L. Nature 425, 516–521 (2003).
Janeway, C. A. Jr Cold Spring Harb. Symp. Quant. Biol. 54, 1–13 (1989).
Medzhitov, R. & Janeway, C. A. Jr Science 296, 298–300 (2002).
Takeda, K., Kaisho, T. & Akira, S. Annu. Rev. Immunol. 21, 335–376 (2003).
Matzinger, P. Annu. Rev. Immunol. 12, 991–1045 (1994).
Matzinger, P. Science 296, 301–305 (2002).
Srivastava, P. Nature Rev. Immunol. 2, 185–194 (2002).
Sauter, B. et al. J. Exp. Med. 191, 423–434 (2000).
Gallucci, S., Lolkema, M. & Matzinger, P. Nature Med. 5, 1249–1255 (1999).
Shi, Y., Zheng, W. & Rock, K. L. Proc. Natl Acad. Sci. USA 97, 14590–14595 (2000).
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Heath, W., Carbone, F. Dangerous liaisons. Nature 425, 460–461 (2003). https://doi.org/10.1038/425460a
Issue Date:
DOI: https://doi.org/10.1038/425460a
This article is cited by
-
A Surprising Role for Uric Acid: The Inflammatory Malaria Response
Current Rheumatology Reports (2014)
-
Pulmonary dendritic cell development and antigen acquisition
Immunologic Research (2013)
-
Cutaneous Perspectives on Adaptive Immunity
Clinical Reviews in Allergy & Immunology (2007)
-
Purinergic mechanism in the immune system: A signal of danger for dendritic cells
Purinergic Signalling (2005)