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Nature 425, 139-141 (11 September 2003) | doi:10.1038/425139a
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Head-Preclinical
- Syngene International
- Bangalore, Karnataka 560099 India
Postdoctoral Opportunity in Cancer Research - Molecular Biologist / Molecular Pathologist, at the IARC / WHO in Lyons, France : Lyons, France
- International Agency for Research on Cancer (IARC / WHO)
- Lyon 69008 France
Cardiovascular biology: Signalling silenced
Edward M. Conway1 & Peter Carmeliet1
Abstract
The mechanism by which the TIMP-2 protein inhibits blood-vessel formation has been uncovered — and it is not as expected. The finding has implications for treating a cancer by cutting off its blood supply.
Tumours and inflamed tissues cannot grow without blood vessels to supply them with oxygen. So interfering with the formation of new blood vessels has been proposed as an attractive means of combating both cancer and inflammation1.
- Centre for Transgene Technology and Gene Therapy, Flanders Interuniversity Institute for Biotechnology, University of Leuven, B-3000 Leuven, Belgium.
Correspondence to: Peter Carmeliet1 Email: peter.carmeliet@med.kuleuven.ac.be
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