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Nature 425, 139-141 (11 September 2003) | doi:10.1038/425139a
Cardiovascular biology: Signalling silenced
Edward M. Conway1 & Peter Carmeliet1
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Abstract
The mechanism by which the TIMP-2 protein inhibits blood-vessel formation has been uncovered — and it is not as expected. The finding has implications for treating a cancer by cutting off its blood supply.
Tumours and inflamed tissues cannot grow without blood vessels to supply them with oxygen. So interfering with the formation of new blood vessels has been proposed as an attractive means of combating both cancer and inflammation1.
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